Hyaluronidase-facilitated high-dose subcutaneous igg effectively controls parvovirus b19 infection in a pediatric cardiac transplant patient with severe t-cell lymphopenia

Rachel J. Cruz; Joseph F. Dasso; Carla Duff; Diane Krasnopero; Zsofia Long; Maryssa Ellison; Daime Nieves; Panida Sriaroon; Alfred Asante-Korang; Jolan E. Walter

doi:10.1093/OFID/OFAA076

Hyaluronidase-facilitated high-dose subcutaneous igg effectively controls parvovirus b19 infection in a pediatric cardiac transplant patient with severe t-cell lymphopenia

Rachel J. Cruz, Joseph F. Dasso, Carla Duff, Diane Krasnopero, Zsofia Long, Maryssa Ellison, Daime Nieves, Panida Sriaroon, Alfred Asante-Korang, Jolan E. Walter

Research output: Contribution to journal › Article › peer-review

Abstract

We treated three pediatric cardiac transplant patients with chronic parvovirus viremia with high-dose intravenous immunoglobulin (HD-IVIG). One patient with severe T-cell lymphopenia suffered recurrent viremia and aseptic meningitis, which resolved remarkably when he was switched to highdose hyaluronidase-facilitated subcutaneous immunoglobulin (HD-SCIG-Hy). We discuss the advantages of HD-SCIG-Hy vs HD-IVIG treatment for similar cases.

Original language	English (US)
Article number	ofaa076
Journal	Open Forum Infectious Diseases
Volume	7
Issue number	5
DOIs	https://doi.org/10.1093/OFID/OFAA076
State	Published - 2020
Externally published	Yes

Keywords

Heart transplant
Immunodeficiency
Parvovirus B19
Pediatric
Subcutaneous immunoglobulin

ASJC Scopus subject areas

Infectious Diseases
Oncology

Access to Document

10.1093/OFID/OFAA076

Cite this

Cruz, R. J., Dasso, J. F., Duff, C., Krasnopero, D., Long, Z., Ellison, M., Nieves, D., Sriaroon, P., Asante-Korang, A., & Walter, J. E. (2020). Hyaluronidase-facilitated high-dose subcutaneous igg effectively controls parvovirus b19 infection in a pediatric cardiac transplant patient with severe t-cell lymphopenia. Open Forum Infectious Diseases, 7(5), Article ofaa076. https://doi.org/10.1093/OFID/OFAA076

Cruz, RJ, Dasso, JF, Duff, C, Krasnopero, D, Long, Z, Ellison, M, Nieves, D, Sriaroon, P, Asante-Korang, A & Walter, JE 2020, 'Hyaluronidase-facilitated high-dose subcutaneous igg effectively controls parvovirus b19 infection in a pediatric cardiac transplant patient with severe t-cell lymphopenia', Open Forum Infectious Diseases, vol. 7, no. 5, ofaa076. https://doi.org/10.1093/OFID/OFAA076

@article{32d130be64104df9bce5978e0c1cc5f3,

title = "Hyaluronidase-facilitated high-dose subcutaneous igg effectively controls parvovirus b19 infection in a pediatric cardiac transplant patient with severe t-cell lymphopenia",

abstract = "We treated three pediatric cardiac transplant patients with chronic parvovirus viremia with high-dose intravenous immunoglobulin (HD-IVIG). One patient with severe T-cell lymphopenia suffered recurrent viremia and aseptic meningitis, which resolved remarkably when he was switched to highdose hyaluronidase-facilitated subcutaneous immunoglobulin (HD-SCIG-Hy). We discuss the advantages of HD-SCIG-Hy vs HD-IVIG treatment for similar cases.",

keywords = "Heart transplant, Immunodeficiency, Parvovirus B19, Pediatric, Subcutaneous immunoglobulin",

author = "Cruz, {Rachel J.} and Dasso, {Joseph F.} and Carla Duff and Diane Krasnopero and Zsofia Long and Maryssa Ellison and Daime Nieves and Panida Sriaroon and Alfred Asante-Korang and Walter, {Jolan E.}",

year = "2020",

doi = "10.1093/OFID/OFAA076",

language = "English (US)",

volume = "7",

journal = "Open Forum Infectious Diseases",

issn = "2328-8957",

publisher = "Oxford University Press",

number = "5",

}

TY - JOUR

T1 - Hyaluronidase-facilitated high-dose subcutaneous igg effectively controls parvovirus b19 infection in a pediatric cardiac transplant patient with severe t-cell lymphopenia

AU - Cruz, Rachel J.

AU - Dasso, Joseph F.

AU - Duff, Carla

AU - Krasnopero, Diane

AU - Long, Zsofia

AU - Ellison, Maryssa

AU - Nieves, Daime

AU - Sriaroon, Panida

AU - Asante-Korang, Alfred

AU - Walter, Jolan E.

PY - 2020

Y1 - 2020

N2 - We treated three pediatric cardiac transplant patients with chronic parvovirus viremia with high-dose intravenous immunoglobulin (HD-IVIG). One patient with severe T-cell lymphopenia suffered recurrent viremia and aseptic meningitis, which resolved remarkably when he was switched to highdose hyaluronidase-facilitated subcutaneous immunoglobulin (HD-SCIG-Hy). We discuss the advantages of HD-SCIG-Hy vs HD-IVIG treatment for similar cases.

AB - We treated three pediatric cardiac transplant patients with chronic parvovirus viremia with high-dose intravenous immunoglobulin (HD-IVIG). One patient with severe T-cell lymphopenia suffered recurrent viremia and aseptic meningitis, which resolved remarkably when he was switched to highdose hyaluronidase-facilitated subcutaneous immunoglobulin (HD-SCIG-Hy). We discuss the advantages of HD-SCIG-Hy vs HD-IVIG treatment for similar cases.

KW - Heart transplant

KW - Immunodeficiency

KW - Parvovirus B19

KW - Pediatric

KW - Subcutaneous immunoglobulin

UR - http://www.scopus.com/inward/record.url?scp=85101400266&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85101400266&partnerID=8YFLogxK

U2 - 10.1093/OFID/OFAA076

DO - 10.1093/OFID/OFAA076

M3 - Article

AN - SCOPUS:85101400266

SN - 2328-8957

VL - 7

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

IS - 5

M1 - ofaa076

ER -

Hyaluronidase-facilitated high-dose subcutaneous igg effectively controls parvovirus b19 infection in a pediatric cardiac transplant patient with severe t-cell lymphopenia

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this