Hyaluronan homeostasis and its role in pain and muscle stiffness

Adam Amir; Soo Kim; Antonio Stecco; Michael P. Jankowski; Preeti Raghavan

doi:10.1002/pmrj.12771

Hyaluronan homeostasis and its role in pain and muscle stiffness

Adam Amir, Soo Kim, Antonio Stecco, Michael P. Jankowski, Preeti Raghavan

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Hyaluronan (HA) is a glycosaminoglycan that consists of single-chain polymers of disaccharide units of glucuronic acid and N-acetylglucosamine. It is a chief constituent of the extracellular matrix. About 27% of the total HA in the body is expressed in the skeleton and connective tissue, while 8% is expressed in muscles. In physiological conditions, HA functions as a lubricant and viscoelastic shock absorber. Additionally, HA is part of complex cellular signaling which modulates nociception and inflammation. This study aims to understand the role that HA plays in the musculoskeletal system, specifically in muscles and the surrounding fascia. This review is also intended to further understand HA homeostasis and the process of its synthesis, degradation, and clearance from the local tissue. The authors examined muscle pain and stiffness as pathological conditions associated with HA accumulation.

Original language	English (US)
Pages (from-to)	1490-1496
Number of pages	7
Journal	PM and R
Volume	14
Issue number	12
DOIs	https://doi.org/10.1002/pmrj.12771
State	Published - Dec 2022

ASJC Scopus subject areas

Physical Therapy, Sports Therapy and Rehabilitation
Rehabilitation
Neurology
Clinical Neurology

Access to Document

10.1002/pmrj.12771

Cite this

@article{9e49033a7de04b589b251e3ba1310150,

title = "Hyaluronan homeostasis and its role in pain and muscle stiffness",

abstract = "Hyaluronan (HA) is a glycosaminoglycan that consists of single-chain polymers of disaccharide units of glucuronic acid and N-acetylglucosamine. It is a chief constituent of the extracellular matrix. About 27% of the total HA in the body is expressed in the skeleton and connective tissue, while 8% is expressed in muscles. In physiological conditions, HA functions as a lubricant and viscoelastic shock absorber. Additionally, HA is part of complex cellular signaling which modulates nociception and inflammation. This study aims to understand the role that HA plays in the musculoskeletal system, specifically in muscles and the surrounding fascia. This review is also intended to further understand HA homeostasis and the process of its synthesis, degradation, and clearance from the local tissue. The authors examined muscle pain and stiffness as pathological conditions associated with HA accumulation.",

author = "Adam Amir and Soo Kim and Antonio Stecco and Jankowski, {Michael P.} and Preeti Raghavan",

note = "Funding Information: This work was supported by grants to MPJ from the NIH/NINDS (R01NS113965 to MPJ) and the Sheikh Khalifa Stroke Institute (PR). Open access funding enabled and organized by Projekt DEAL. Publisher Copyright: {\textcopyright} 2022 The Authors. PM&R published by Wiley Periodicals LLC on behalf of American Academy of Physical Medicine and Rehabilitation.",

year = "2022",

month = dec,

doi = "10.1002/pmrj.12771",

language = "English (US)",

volume = "14",

pages = "1490--1496",

journal = "PM and R",

issn = "1934-1482",

publisher = "Elsevier Inc.",

number = "12",

}

TY - JOUR

T1 - Hyaluronan homeostasis and its role in pain and muscle stiffness

AU - Amir, Adam

AU - Kim, Soo

AU - Stecco, Antonio

AU - Jankowski, Michael P.

AU - Raghavan, Preeti

N1 - Funding Information: This work was supported by grants to MPJ from the NIH/NINDS (R01NS113965 to MPJ) and the Sheikh Khalifa Stroke Institute (PR). Open access funding enabled and organized by Projekt DEAL. Publisher Copyright: © 2022 The Authors. PM&R published by Wiley Periodicals LLC on behalf of American Academy of Physical Medicine and Rehabilitation.

PY - 2022/12

Y1 - 2022/12

N2 - Hyaluronan (HA) is a glycosaminoglycan that consists of single-chain polymers of disaccharide units of glucuronic acid and N-acetylglucosamine. It is a chief constituent of the extracellular matrix. About 27% of the total HA in the body is expressed in the skeleton and connective tissue, while 8% is expressed in muscles. In physiological conditions, HA functions as a lubricant and viscoelastic shock absorber. Additionally, HA is part of complex cellular signaling which modulates nociception and inflammation. This study aims to understand the role that HA plays in the musculoskeletal system, specifically in muscles and the surrounding fascia. This review is also intended to further understand HA homeostasis and the process of its synthesis, degradation, and clearance from the local tissue. The authors examined muscle pain and stiffness as pathological conditions associated with HA accumulation.

AB - Hyaluronan (HA) is a glycosaminoglycan that consists of single-chain polymers of disaccharide units of glucuronic acid and N-acetylglucosamine. It is a chief constituent of the extracellular matrix. About 27% of the total HA in the body is expressed in the skeleton and connective tissue, while 8% is expressed in muscles. In physiological conditions, HA functions as a lubricant and viscoelastic shock absorber. Additionally, HA is part of complex cellular signaling which modulates nociception and inflammation. This study aims to understand the role that HA plays in the musculoskeletal system, specifically in muscles and the surrounding fascia. This review is also intended to further understand HA homeostasis and the process of its synthesis, degradation, and clearance from the local tissue. The authors examined muscle pain and stiffness as pathological conditions associated with HA accumulation.

UR - http://www.scopus.com/inward/record.url?scp=85125260620&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85125260620&partnerID=8YFLogxK

U2 - 10.1002/pmrj.12771

DO - 10.1002/pmrj.12771

M3 - Review article

C2 - 35077007

AN - SCOPUS:85125260620

SN - 1934-1482

VL - 14

SP - 1490

EP - 1496

JO - PM and R

JF - PM and R

IS - 12

ER -

Hyaluronan homeostasis and its role in pain and muscle stiffness

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this