TY - JOUR
T1 - Huntington's disease
T2 - New paths to pathogenesis
AU - Ross, Christopher A.
N1 - Funding Information:
I thank L.M. Ellerby and R.L. Margolis for critical reading of the manuscript. Supported by NINDS, Huntington's Disease Society of America, Hereditary Disease Foundation, and High-Q Foundation.
PY - 2004/7/9
Y1 - 2004/7/9
N2 - Huntington's disease is a progressive autosomal dominant neurodegenerative disorder caused by expansion of a CAG repeat coding for polyglutamine in the huntingtin protein. A recent report (Gauthier et al., 2004, this issue of Cell) suggests a new mechanism involving altered interactions with a protein involved in axonal transport, leading to loss of neurotrophic factor transport. This suggests an intriguing convergence to previously described pathways implicating neurotrophin transcription in HD pathogenesis.
AB - Huntington's disease is a progressive autosomal dominant neurodegenerative disorder caused by expansion of a CAG repeat coding for polyglutamine in the huntingtin protein. A recent report (Gauthier et al., 2004, this issue of Cell) suggests a new mechanism involving altered interactions with a protein involved in axonal transport, leading to loss of neurotrophic factor transport. This suggests an intriguing convergence to previously described pathways implicating neurotrophin transcription in HD pathogenesis.
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U2 - 10.1016/j.cell.2004.06.022
DO - 10.1016/j.cell.2004.06.022
M3 - Review article
C2 - 15242639
AN - SCOPUS:3142640821
SN - 0092-8674
VL - 118
SP - 4
EP - 7
JO - Cell
JF - Cell
IS - 1
ER -