Huntington's disease: New paths to pathogenesis

Research output: Contribution to journalReview articlepeer-review

Abstract

Huntington's disease is a progressive autosomal dominant neurodegenerative disorder caused by expansion of a CAG repeat coding for polyglutamine in the huntingtin protein. A recent report (Gauthier et al., 2004, this issue of Cell) suggests a new mechanism involving altered interactions with a protein involved in axonal transport, leading to loss of neurotrophic factor transport. This suggests an intriguing convergence to previously described pathways implicating neurotrophin transcription in HD pathogenesis.

Original languageEnglish (US)
Pages (from-to)4-7
Number of pages4
JournalCell
Volume118
Issue number1
DOIs
StatePublished - Jul 9 2004

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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