Huntington's Disease-like 2

R. L. Margolis; D. D. Rudnicki; S. E. Holmes

doi:10.1016/B978-0-12-374105-9.00404-4

Huntington's Disease-like 2

R. L. Margolis, D. D. Rudnicki, S. E. Holmes

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Huntington's disease-like 2 (HDL2) is a rare, autosomal dominant, adult-onset, progressive neurodegenerative disorder, genetically, clinically, and pathologically nearly indistinguishable from Huntington's disease (HD). HDL2 is caused by a trinucleotide repeat expansion detectable by genetic testing. Understanding HDL2 may provide clues to the pathogenesis of HD and other neurodegenerative diseases.

Original language	English (US)
Title of host publication	Encyclopedia of Movement Disorders
Publisher	Elsevier Inc.
Pages	36-38
Number of pages	3
ISBN (Electronic)	9780123741059
ISBN (Print)	9780123741011
DOIs	https://doi.org/10.1016/B978-0-12-374105-9.00404-4
State	Published - Jan 1 2010

Keywords

Atrophy
Caudate
Chorea
Dementia
Dominant
Familial
Hereditary
Huntington
Junctophilin
Neurodegeneration
Neurotoxicity
RNA
Repeat
Striatum
Trinucleotide

ASJC Scopus subject areas

General Medicine
General Neuroscience

Access to Document

10.1016/B978-0-12-374105-9.00404-4

Cite this

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title = "Huntington's Disease-like 2",

abstract = "Huntington's disease-like 2 (HDL2) is a rare, autosomal dominant, adult-onset, progressive neurodegenerative disorder, genetically, clinically, and pathologically nearly indistinguishable from Huntington's disease (HD). HDL2 is caused by a trinucleotide repeat expansion detectable by genetic testing. Understanding HDL2 may provide clues to the pathogenesis of HD and other neurodegenerative diseases.",

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AU - Margolis, R. L.

AU - Rudnicki, D. D.

AU - Holmes, S. E.

PY - 2010/1/1

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N2 - Huntington's disease-like 2 (HDL2) is a rare, autosomal dominant, adult-onset, progressive neurodegenerative disorder, genetically, clinically, and pathologically nearly indistinguishable from Huntington's disease (HD). HDL2 is caused by a trinucleotide repeat expansion detectable by genetic testing. Understanding HDL2 may provide clues to the pathogenesis of HD and other neurodegenerative diseases.

AB - Huntington's disease-like 2 (HDL2) is a rare, autosomal dominant, adult-onset, progressive neurodegenerative disorder, genetically, clinically, and pathologically nearly indistinguishable from Huntington's disease (HD). HDL2 is caused by a trinucleotide repeat expansion detectable by genetic testing. Understanding HDL2 may provide clues to the pathogenesis of HD and other neurodegenerative diseases.

KW - Atrophy

KW - Caudate

KW - Chorea

KW - Dementia

KW - Dominant

KW - Familial

KW - Hereditary

KW - Huntington

KW - Junctophilin

KW - Neurodegeneration

KW - Neurotoxicity

KW - RNA

KW - Repeat

KW - Striatum

KW - Trinucleotide

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M3 - Chapter

AN - SCOPUS:85069830263

SN - 9780123741011

SP - 36

EP - 38

BT - Encyclopedia of Movement Disorders

PB - Elsevier Inc.

ER -

Huntington's Disease-like 2

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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