Huntington's Disease-like 2

R. L. Margolis, Dobrila Rudnicki, Susan Elizabeth Holmes

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Huntington's disease-like 2 (HDL2) is a rare, autosomal dominant, adult-onset, progressive neurodegenerative disorder, genetically, clinically, and pathologically nearly indistinguishable from Huntington's disease (HD). HDL2 is caused by a trinucleotide repeat expansion detectable by genetic testing. Understanding HDL2 may provide clues to the pathogenesis of HD and other neurodegenerative diseases.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Movement Disorders
PublisherElsevier Inc.
Pages36-38
Number of pages3
ISBN (Electronic)9780123741059
ISBN (Print)9780123741011
DOIs
StatePublished - Jan 1 2010

Keywords

  • Atrophy
  • Caudate
  • Chorea
  • Dementia
  • Dominant
  • Familial
  • Hereditary
  • Huntington
  • Junctophilin
  • Neurodegeneration
  • Neurotoxicity
  • Repeat
  • RNA
  • Striatum
  • Trinucleotide

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

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