Humoral and cellular immune responses to matrix protein of measles virus in subacute sclerosing panencephalitis

S. Dhib-Jalbut, H. F. McFarland, E. S. Mingioli, J. L. Sever, D. E. McFarlin

Research output: Contribution to journalArticle

Abstract

The immune response to matrix (M) protein of measles virus was examined in patients with subacute sclerosing panencephalitis (SSPE) and controls. Antibodies specific for M and nucleocapsid (NC) proteins in 11 serum and 8 cerebrospinal fluid (CSF) samples from patients with SSPE were quantitated by enzyme-linked immunosorbent assay by using affinity-purified measles virus proteins. Geometric mean anti-NC antibody titers were higher in the serum (6.58 ± 0.98 [mean ± standard deviation]) and CSF (4.38 ± 0.74) of SSPE patients compared with controls. Anti-M antibodies were present in the serum and CSF of all SSPE samples tested but in titers lower than those of anti-NC antibodies. Geometric mean anti-M antibody titer was 3.35 ± 0.53 in sera from patients with SSPE compared with 3.05 ± 0.66 in sera from patients with other neurological diseases and 3.12 ± 0.74 in sera from healthy individuals. Geometric mean anti-M antibody titer was 2.59 ± 0.86 in the CSF of eight patients with SSPE compared with a mean

Original languageEnglish (US)
Pages (from-to)2483-2489
Number of pages7
JournalJournal of Virology
Volume62
Issue number7
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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    Dhib-Jalbut, S., McFarland, H. F., Mingioli, E. S., Sever, J. L., & McFarlin, D. E. (1988). Humoral and cellular immune responses to matrix protein of measles virus in subacute sclerosing panencephalitis. Journal of Virology, 62(7), 2483-2489.