Humanizing π-class glutathione s-transferase regulation in a mouse model alters liver toxicity in response to acetaminophen overdose

Agriculture & Biology

• overdose 100%
• acetaminophen 93%
• hepatotoxicity 89%
• transferases 73%
• animal models 64%
• glutathione 61%
• glutathione transferase 55%
• mice 37%
• hepatocytes 29%
• toxicology 18%
• xenobiotics 17%
• drugs 16%
• toxins 13%
• Kupffer cells 11%
• enzymes 10%
• bisulfites 10%
• bile ducts 10%
• DNA methylation 8%
• endothelial cells 8%
• transgenes 7%
• sequence homology 7%
• necrosis 7%
• exons 7%
• macrophages 7%
• epithelial cells 7%
• germ cells 6%
• amino acid sequences 5%
• promoter regions 5%
• genomics 5%
• nucleotide sequences 5%
• dosage 4%
• tissues 3%
• genes 2%
• proteins 2%
• cells 2%
• methodology 2%

Medicine & Life Sciences

• Glutathione Transferase 78%
• Acetaminophen 77%
• Liver 37%
• Hepatocytes 27%
• Xenobiotics 17%
• Toxicology 15%
• Prostate 13%
• Enzymes 13%
• Amino Acid Sequence Homology 11%
• hydrogen sulfite 10%
• Pharmaceutical Preparations 10%
• CpG Islands 9%
• Kupffer Cells 9%
• Bile Ducts 8%
• Transgenes 8%
• DNA Methylation 8%
• Wounds and Injuries 7%
• Introns 7%
• Exons 6%
• Genes 6%
• Necrosis 6%
• Endothelial Cells 6%
• Epithelial Cells 5%
• Macrophages 5%
• Messenger RNA 4%
• Proteins 3%

Chemical Compounds

• Glutathione 65%
• Xenobiotic Agent 24%
• Drug 16%
• Toxin 10%
• Protein 8%
• Dose 8%
• Strain 7%