Humanized antibodies as potential therapeutic drugs

Surender K. Vaswani, Robert G Hamilton

Research output: Contribution to journalArticle

Abstract

Background: Antibodies have been used therapeutically to treat a variety of clinical conditions. The introduction of monoclonal antibodies and more recently, engineered humanized antibodies has greatly refined and expanded the therapeutic potential of this modality of treatment. Learning Objectives: To reinforce the reader's knowledge of the therapeutic application of antibody in the treatment for different diseases. More specifically, to enhance reader's understanding of basic methods employed in the production and clinical use of humanized antibodies. Data Source: The MEDLINE database was used to review the humanized antibody related literature. Conclusion: Humanized antibodies provide a novel approach for the treatment of a broad range of diseases. Expanded use will depend on improvement in their efficacy (avidity and specificity), demonstration of their safety, and reduction of their immunogenicity.

Original languageEnglish (US)
Pages (from-to)105-119
Number of pages15
JournalAnnals of Allergy, Asthma and Immunology
Volume81
Issue number2
Publication statusPublished - Aug 1998

    Fingerprint

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this