Human uterine arterial relaxation induced by nitroxidergic nerve stimulation

N. Toda, T. Kimura, K. Yoshida, D. S. Bredt, Solomon H Snyder, Y. Yoshida, T. Okamura

Research output: Contribution to journalArticle

Abstract

Uterine arterial strips obtained from humans responded to nicotine with a contraction, which was abolished by prazosin. In the arteries treated with the α1-receptor antagonist and partially contracted with serotonin, nicotine produced a relaxation that was not influenced by treatment with atropine or timolol and endothelium denudation but was abolished by hexamethonium, oxyhemoglobin, and N(G)-nitro-L-arginine (L-NNA). The inhibitory effect of L-NNA was reversed by L- but not D-arginine. Relaxations induced by nitroglycerin and nitric oxide (NO) were not affected by L-NNA but were abolished by oxyhemoglobin. Transmural electrical stimulation relaxed the arterial strips treated with prazosin; this response was abolished by L- NNA and restored by L-arginine. Histochemical study with NO synthase antiserum demonstrated the presence of immunoreactive nerve fibers in the adventitia. It may be concluded that human uterine arteries are innervated by vasodilator nerves that liberate NO as a neurotransmitter after chemical or electrical stimulation. Predominant vasoconstriction due to nerve stimulation appears to be associated with activation of α1-adrenoceptors by neurogenic norepinephrine.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume266
Issue number4 35-4
StatePublished - 1994
Externally publishedYes

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Nitrergic Neurons
arginine
Arginine
Oxyhemoglobins
nerve tissue
Prazosin
nicotine
Nicotine
arteries
Electric Stimulation
nitric oxide
Nitric Oxide
Chemical Stimulation
Timolol
Uterine Artery
Adventitia
Hexamethonium
vasodilator agents
vasoconstriction
atropine

Keywords

  • immunohistochemistry
  • nitric oxide
  • nitric oxide synthase inhibitor
  • vasodilator innervation

ASJC Scopus subject areas

  • Physiology
  • Agricultural and Biological Sciences(all)

Cite this

Human uterine arterial relaxation induced by nitroxidergic nerve stimulation. / Toda, N.; Kimura, T.; Yoshida, K.; Bredt, D. S.; Snyder, Solomon H; Yoshida, Y.; Okamura, T.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 266, No. 4 35-4, 1994.

Research output: Contribution to journalArticle

Toda, N. ; Kimura, T. ; Yoshida, K. ; Bredt, D. S. ; Snyder, Solomon H ; Yoshida, Y. ; Okamura, T. / Human uterine arterial relaxation induced by nitroxidergic nerve stimulation. In: American Journal of Physiology - Heart and Circulatory Physiology. 1994 ; Vol. 266, No. 4 35-4.
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AU - Kimura, T.

AU - Yoshida, K.

AU - Bredt, D. S.

AU - Snyder, Solomon H

AU - Yoshida, Y.

AU - Okamura, T.

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