Human tumor-infiltrating lymphocytes

K. Itoh, Charles M. Balch, A. C. Von Eschenbach, T. Morita, K. Hayakawa, D. Seito

Research output: Contribution to journalArticle

Abstract

We review seven key areas in human tumor-infiltrating lymphocyte (TIL) research: yield, subpopulation phenotypes, interleukin 2 (IL-2)-induced proliferation, cytotoxicity, lymphokine production, oligoclonality, and T cell receptor (TCR) Vα and Vβ gene usage of tumor-specific T cells. Most cancers contain a significant infiltration of lymphocytes. T cells, in particular CD4+ T cells, were the predominant population. IL-2-induced TIL proliferation was greater than that of peripheral blood mononuclear cells (PBMCs). IL-2-activated TILs from some cancers (melanoma, bladder cancer, and glioma) displayed autologous tumor-specific cytotoxicity, whereas those from other cancers primarily had major histocompatibility complex (MHC)- nonrestricted cytotoxicity (renal cell carcinoma (RCC), head and neck cancer, and liver carcinoma). MHC-nonrestricted interferon-γ (IFN-γ) production was characteristic of IL-2-activated TILs in most cases of melanomas and RCCs. In contrast to PBMCs or lymphocytes from normal tissues, T cells from TILs of most melanomas and RCCs displayed oligoclonality following activation with IL-2. Usage of TCR Vα or Vβ gene for melanoma-specific cytotoxic T lymphocyte (CTL) clones that were derived from TIL was not restricted to one or several genes, but was rather diverse. In summary, TIL contains tumor- specific T cells and therefore will be an appropriate source for understanding the cellular and molecular basis of host-tumor interaction.

Original languageEnglish (US)
Pages (from-to)117-123
Number of pages7
JournalGann Monographs on Cancer Research
Volume40
StatePublished - 1993
Externally publishedYes

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Tumor-Infiltrating Lymphocytes
Interleukin-2
Melanoma
T-Lymphocytes
Neoplasms
T-Cell Antigen Receptor
Major Histocompatibility Complex
Renal Cell Carcinoma
Urinary Bladder Neoplasms
Blood Cells
Lymphocytes
Genes
Lymphokines
Cytotoxic T-Lymphocytes
Liver Neoplasms
Head and Neck Neoplasms
Glioma
Interferons
Clone Cells
Carcinoma

ASJC Scopus subject areas

  • Cancer Research

Cite this

Itoh, K., Balch, C. M., Von Eschenbach, A. C., Morita, T., Hayakawa, K., & Seito, D. (1993). Human tumor-infiltrating lymphocytes. Gann Monographs on Cancer Research, 40, 117-123.

Human tumor-infiltrating lymphocytes. / Itoh, K.; Balch, Charles M.; Von Eschenbach, A. C.; Morita, T.; Hayakawa, K.; Seito, D.

In: Gann Monographs on Cancer Research, Vol. 40, 1993, p. 117-123.

Research output: Contribution to journalArticle

Itoh, K, Balch, CM, Von Eschenbach, AC, Morita, T, Hayakawa, K & Seito, D 1993, 'Human tumor-infiltrating lymphocytes', Gann Monographs on Cancer Research, vol. 40, pp. 117-123.
Itoh K, Balch CM, Von Eschenbach AC, Morita T, Hayakawa K, Seito D. Human tumor-infiltrating lymphocytes. Gann Monographs on Cancer Research. 1993;40:117-123.
Itoh, K. ; Balch, Charles M. ; Von Eschenbach, A. C. ; Morita, T. ; Hayakawa, K. ; Seito, D. / Human tumor-infiltrating lymphocytes. In: Gann Monographs on Cancer Research. 1993 ; Vol. 40. pp. 117-123.
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AU - Seito, D.

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