Human T-lymphotropic virus type II infection in Vietnamese thalassemic patients

M. T. Lin, B. T. Nguyen, T. V. Binh, T. V. Be, T. Y. Chiang, L. H. Tseng, Y. C. Yang, K. H. Lin, Y. C. Chen

Research output: Contribution to journalArticlepeer-review


Anti-human T-lymphotropic virus type I/II (HTLV-I/II) antibodies were screened by particle agglutination test in a total of 66 patients with thalassemia major who received multiple transfusion from paid donors at the Blood Transfusion Hematology Center of Ho Chi Minh City in South Vietnam. HTLV-II infection was confirmed in 6 patients (9.1%) by Western blot analysis and/or polymerase chain reaction. Phylogenetic analysis revealed that long terminal repeat sequences of HTLV-II proviruses from 5 thalassemic patients in Vietnam belonged to the same phylogenetic subgroup of HTLV-IIb as those from intravenous drug abusers in North America and Europe. These data shed light on the route of introducing HTLV-II into Vietnam.

Original languageEnglish (US)
Pages (from-to)1429-1440
Number of pages12
JournalArchives of Virology
Issue number7
StatePublished - Aug 5 1997
Externally publishedYes

ASJC Scopus subject areas

  • Virology

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