Human T-cell lymphotropic virus type III shares sequence homology with a family of pathogenic lentiviruses

M. A. Gonda, M. J. Braun, Janice E Clements, J. M. Pyper, F. Wong-Staal, R. C. Gallo, R. V. Gilden

Research output: Contribution to journalArticle

Abstract

The etiologic agent of the acquired immune deficiency syndrome, human T-cell lymphotropic virus type III (HTLV-III), has recently been shown to morphologically resemble and share sequence homology with visna virus, a pathogenic lentivirus. Molecular hybridization, heteroduplex mapping, and DNA sequence analyses were used to compare HTLV-III to other lentiviruses of domestic animals, including visna, caprine arthritis encephalitis, and equine infectious anemia viruses. Hybridization results showed that a substantial amount of sequence homology exists between each of these viruses and HTLV-III. In addition, a closer relationship was found between visna and caprine arthritis encephalitis viruses than for any of the other lentiviruses studied. These results, along with nucleotide and amino acid sequence comparisons, have been used in a comprehensive effort to derive a systematic relationship for lentiviruses and to provide further evidence for classifying HTLV-III with the Lentivirinae subfamily of retroviruses. This relationship predicts that similarities in biology and disease process can be expected between HTLV-III and other Lentivirinae members.

Original languageEnglish (US)
Pages (from-to)4007-4011
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume83
Issue number11
StatePublished - 1986
Externally publishedYes

Fingerprint

Lentivirus
Sequence Homology
HIV
Visna
Caprine Arthritis-Encephalitis Viruses
Visna-maedi virus
Equine infectious anemia virus
Nucleic Acid Heteroduplexes
Domestic Animals
Encephalitis
Retroviridae
DNA Sequence Analysis
Arthritis
Amino Acid Sequence
Acquired Immunodeficiency Syndrome
Nucleotides
Viruses

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Human T-cell lymphotropic virus type III shares sequence homology with a family of pathogenic lentiviruses. / Gonda, M. A.; Braun, M. J.; Clements, Janice E; Pyper, J. M.; Wong-Staal, F.; Gallo, R. C.; Gilden, R. V.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 83, No. 11, 1986, p. 4007-4011.

Research output: Contribution to journalArticle

Gonda, M. A. ; Braun, M. J. ; Clements, Janice E ; Pyper, J. M. ; Wong-Staal, F. ; Gallo, R. C. ; Gilden, R. V. / Human T-cell lymphotropic virus type III shares sequence homology with a family of pathogenic lentiviruses. In: Proceedings of the National Academy of Sciences of the United States of America. 1986 ; Vol. 83, No. 11. pp. 4007-4011.
@article{691d9fa86ede46b68f4c166111a4d73b,
title = "Human T-cell lymphotropic virus type III shares sequence homology with a family of pathogenic lentiviruses",
abstract = "The etiologic agent of the acquired immune deficiency syndrome, human T-cell lymphotropic virus type III (HTLV-III), has recently been shown to morphologically resemble and share sequence homology with visna virus, a pathogenic lentivirus. Molecular hybridization, heteroduplex mapping, and DNA sequence analyses were used to compare HTLV-III to other lentiviruses of domestic animals, including visna, caprine arthritis encephalitis, and equine infectious anemia viruses. Hybridization results showed that a substantial amount of sequence homology exists between each of these viruses and HTLV-III. In addition, a closer relationship was found between visna and caprine arthritis encephalitis viruses than for any of the other lentiviruses studied. These results, along with nucleotide and amino acid sequence comparisons, have been used in a comprehensive effort to derive a systematic relationship for lentiviruses and to provide further evidence for classifying HTLV-III with the Lentivirinae subfamily of retroviruses. This relationship predicts that similarities in biology and disease process can be expected between HTLV-III and other Lentivirinae members.",
author = "Gonda, {M. A.} and Braun, {M. J.} and Clements, {Janice E} and Pyper, {J. M.} and F. Wong-Staal and Gallo, {R. C.} and Gilden, {R. V.}",
year = "1986",
language = "English (US)",
volume = "83",
pages = "4007--4011",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
number = "11",

}

TY - JOUR

T1 - Human T-cell lymphotropic virus type III shares sequence homology with a family of pathogenic lentiviruses

AU - Gonda, M. A.

AU - Braun, M. J.

AU - Clements, Janice E

AU - Pyper, J. M.

AU - Wong-Staal, F.

AU - Gallo, R. C.

AU - Gilden, R. V.

PY - 1986

Y1 - 1986

N2 - The etiologic agent of the acquired immune deficiency syndrome, human T-cell lymphotropic virus type III (HTLV-III), has recently been shown to morphologically resemble and share sequence homology with visna virus, a pathogenic lentivirus. Molecular hybridization, heteroduplex mapping, and DNA sequence analyses were used to compare HTLV-III to other lentiviruses of domestic animals, including visna, caprine arthritis encephalitis, and equine infectious anemia viruses. Hybridization results showed that a substantial amount of sequence homology exists between each of these viruses and HTLV-III. In addition, a closer relationship was found between visna and caprine arthritis encephalitis viruses than for any of the other lentiviruses studied. These results, along with nucleotide and amino acid sequence comparisons, have been used in a comprehensive effort to derive a systematic relationship for lentiviruses and to provide further evidence for classifying HTLV-III with the Lentivirinae subfamily of retroviruses. This relationship predicts that similarities in biology and disease process can be expected between HTLV-III and other Lentivirinae members.

AB - The etiologic agent of the acquired immune deficiency syndrome, human T-cell lymphotropic virus type III (HTLV-III), has recently been shown to morphologically resemble and share sequence homology with visna virus, a pathogenic lentivirus. Molecular hybridization, heteroduplex mapping, and DNA sequence analyses were used to compare HTLV-III to other lentiviruses of domestic animals, including visna, caprine arthritis encephalitis, and equine infectious anemia viruses. Hybridization results showed that a substantial amount of sequence homology exists between each of these viruses and HTLV-III. In addition, a closer relationship was found between visna and caprine arthritis encephalitis viruses than for any of the other lentiviruses studied. These results, along with nucleotide and amino acid sequence comparisons, have been used in a comprehensive effort to derive a systematic relationship for lentiviruses and to provide further evidence for classifying HTLV-III with the Lentivirinae subfamily of retroviruses. This relationship predicts that similarities in biology and disease process can be expected between HTLV-III and other Lentivirinae members.

UR - http://www.scopus.com/inward/record.url?scp=0013560719&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0013560719&partnerID=8YFLogxK

M3 - Article

C2 - 2424014

AN - SCOPUS:0013560719

VL - 83

SP - 4007

EP - 4011

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 11

ER -