TY - JOUR
T1 - Human striatal responses to monetary reward depend on saliency
AU - Zink, Caroline F.
AU - Pagnoni, Giuseppe
AU - Martin-Skurski, Megan E.
AU - Chappelow, Jonathan C.
AU - Berns, Gregory S.
N1 - Funding Information:
We thank Milos Cekic for his assistance with the acquisition and analysis of the psychophysical data and his aid in the preparation of the manuscript. We also thank the anonymous reviewers for their constructive comments. This work was supported by grants from the National Institutes of Health, K08 DA00367 and R01 EB002635, to G.S.B and F31 MH067348 to C.F.Z.
PY - 2004/5/13
Y1 - 2004/5/13
N2 - While the striatum has been implicated in reward processing, an alternative view contends that the striatum processes salient events in general. Using fMRI, we investigated human striatal responses to monetary reward while modulating the saliency surrounding its receipt. Money was maximally salient when its receipt depended on a correct response (active) and minimally salient when its receipt was completely independent of the task (passive). The saliency manipulation was confirmed by skin conductance responses and subjective ratings of the stimuli. Significant caudate and nucleus accumbens activations occurred following the active compared to passive money. Such activations were attributed to saliency rather than the motor requirement associated with the active money because striatal activations were not observed when the money was replaced by inconsequential, nonrewarding stimuli. The present study provides evidence that the striatum's role in reward processing is dependent on the saliency associated with reward, rather than value or hedonic feelings.
AB - While the striatum has been implicated in reward processing, an alternative view contends that the striatum processes salient events in general. Using fMRI, we investigated human striatal responses to monetary reward while modulating the saliency surrounding its receipt. Money was maximally salient when its receipt depended on a correct response (active) and minimally salient when its receipt was completely independent of the task (passive). The saliency manipulation was confirmed by skin conductance responses and subjective ratings of the stimuli. Significant caudate and nucleus accumbens activations occurred following the active compared to passive money. Such activations were attributed to saliency rather than the motor requirement associated with the active money because striatal activations were not observed when the money was replaced by inconsequential, nonrewarding stimuli. The present study provides evidence that the striatum's role in reward processing is dependent on the saliency associated with reward, rather than value or hedonic feelings.
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U2 - 10.1016/S0896-6273(04)00183-7
DO - 10.1016/S0896-6273(04)00183-7
M3 - Article
C2 - 15134646
AN - SCOPUS:2342602920
SN - 0896-6273
VL - 42
SP - 509
EP - 517
JO - Neuron
JF - Neuron
IS - 3
ER -