Human sex differentiation: From transcription factors to gender

Claude J. Migeon, Amy B. Wisniewski

Research output: Contribution to journalArticle


Over the past decade, knowledge of the genetic control of human sex differentiation has greately expanded our understanding of the developmental processes needed to form a male or female. The purpose of this review is to discuss how transcription factors are relevant to such processes. Additionally, an attempt is made to relate current knowledge of these factors with gender development of subjects with intersex conditions. Finally, we discuss how information about the genetic control of sex differentiation may contribute to decisions about medical treatment of individuals with conditions of abnormal sex differentiation. Copyright (C) 2000 S. Karger AG, Basel.

Original languageEnglish (US)
Pages (from-to)111-119
Number of pages9
JournalHormone Research
Issue number3
StatePublished - 2000



  • Gender
  • Hormone receptors
  • Sex
  • Sex differentiation
  • Transcription factors

ASJC Scopus subject areas

  • Endocrinology

Cite this

Migeon, C. J., & Wisniewski, A. B. (2000). Human sex differentiation: From transcription factors to gender. Hormone Research, 53(3), 111-119.