Human-rhesus reassortant rotavirus vaccines: Safety and immunogenicity in adults, infants, and children

Neal A. Halsey, Edwin L. Anderson, Stephen D. Sears, Mark Steinhoff, Modena Wilson, Robert B. Belshe, Karen Midthun, Albert Z. Kapiklan, Robert M. Chanock, Roberta Samorodin, Barbara Burns, Mary Lou Clements

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Human-rhesus reassortant rotavirus vaccines derived from rhesus rotavirus and human rotavirus serotypes 1, 2, or 4 were administered to adults, children, and infants after they had been given sodium bicarbonate buffer. Over 70% of infants and children developed antibody responses to or shed the candidate vaccine viruses. Individuals with prevaccination serum neutralization antibody titers ≤1:160 had significantly (P<.0001) higher response rates than did individuals with prevaccination titers ≥1:320. Similarly, shedding of vaccine viruses occurred significantly (P =.03) more often in children than adults and was inversely correlated with prevaccination antibody titers. No illnesses were observed in adults, and the vaccines were well tolerated in children. An increased rate of low-grade, transient fever (38.0-38.8 C) was noted only in children given serotype 2 vaccine, compared with controls (P =.006). No significant differences in the average number of unformed stools passed during the seven days after vaccination were noted in vaccinees versus controls. These vaccine strains are currently undergoing further evaluation in expanded clinical trials.

Original languageEnglish (US)
Pages (from-to)1261-1267
Number of pages7
JournalJournal of Infectious Diseases
Issue number6
StatePublished - Dec 1988

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases


Dive into the research topics of 'Human-rhesus reassortant rotavirus vaccines: Safety and immunogenicity in adults, infants, and children'. Together they form a unique fingerprint.

Cite this