Human reovirus like agent as the major pathogen associated with 'winter' gastroenteritis in hospitalized infants and young children

A. Z. Kapikian, H. W. Kim, R. G. Wyatt, W. L. Cline, J. O. Arrobio, C. D. Brandt, W. J. Rodriguez, David Allen Sack, R. M. Chanock, R. H. Parrott

Research output: Contribution to journalArticle

Abstract

A human reovirus like agent was found in the stools of 42% of 143 infants and young children hospitalized with acute gastroenteritis. Half the patients studied by electron microscopy and serologic technics had evidence of infection with the agent. The infection had a seasonal pattern: 59% of those admitted during the cooler months (November to April) shed the agent, with a peak of 78% in December, 1974, and January, 1975, combined. None of the patients admitted during the warmer months (May to October 1974) shed the agent. None of 275 E. coli isolates from 32 patients with diarrhea produced heat labile enterotoxin, whereas 17 of the 32 had evidence of infection with the reovirus like agent. In addition, 14 of 40 parents of 37 patients with diarrhea associated with the reovirus like agent were also infected, but most infections were inapparent. This agent appears to be the major cause of diarrheal illness in the young during the cooler months.

Original languageEnglish (US)
Pages (from-to)965-972
Number of pages8
JournalNew England Journal of Medicine
Volume294
Issue number18
StatePublished - 1976

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Gastroenteritis
Diarrhea
Reoviridae Infections
Infection
Hospitalized Child
Enterotoxins
Electron Microscopy
Hot Temperature
Parents
Escherichia coli

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kapikian, A. Z., Kim, H. W., Wyatt, R. G., Cline, W. L., Arrobio, J. O., Brandt, C. D., ... Parrott, R. H. (1976). Human reovirus like agent as the major pathogen associated with 'winter' gastroenteritis in hospitalized infants and young children. New England Journal of Medicine, 294(18), 965-972.

Human reovirus like agent as the major pathogen associated with 'winter' gastroenteritis in hospitalized infants and young children. / Kapikian, A. Z.; Kim, H. W.; Wyatt, R. G.; Cline, W. L.; Arrobio, J. O.; Brandt, C. D.; Rodriguez, W. J.; Sack, David Allen; Chanock, R. M.; Parrott, R. H.

In: New England Journal of Medicine, Vol. 294, No. 18, 1976, p. 965-972.

Research output: Contribution to journalArticle

Kapikian, AZ, Kim, HW, Wyatt, RG, Cline, WL, Arrobio, JO, Brandt, CD, Rodriguez, WJ, Sack, DA, Chanock, RM & Parrott, RH 1976, 'Human reovirus like agent as the major pathogen associated with 'winter' gastroenteritis in hospitalized infants and young children', New England Journal of Medicine, vol. 294, no. 18, pp. 965-972.
Kapikian, A. Z. ; Kim, H. W. ; Wyatt, R. G. ; Cline, W. L. ; Arrobio, J. O. ; Brandt, C. D. ; Rodriguez, W. J. ; Sack, David Allen ; Chanock, R. M. ; Parrott, R. H. / Human reovirus like agent as the major pathogen associated with 'winter' gastroenteritis in hospitalized infants and young children. In: New England Journal of Medicine. 1976 ; Vol. 294, No. 18. pp. 965-972.
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