Human Protein Reference Database and Human Proteinpedia as discovery tools for systems biology.

T. S Keshava Prasad, Kumaran Kandasamy, Akhilesh Pandey

Research output: Contribution to journalArticle

Abstract

Although high-throughput technologies used in biology have resulted in the accumulation of vast amounts of data in the literature, it is becoming difficult for individual investigators to directly benefit from this data because they are not easily accessible. Databases have assumed a crucial role in assimilating and storing information that could enable future discoveries. To this end, our group has developed two resources - Human Protein Reference Database (HPRD) and Human Proteinpedia - that provide integrated information pertaining to human proteins. These databases contain information on a number of features of proteins that have been discovered using various experimental methods. Human Proteinpedia was developed as a portal for community participation to annotate and share proteomic data using HPRD as the scaffold. It allows proteomic investigators to even share unpublished data and provides an effective medium for data sharing. As proteomic information reflects a direct view of cellular systems, proteomics is expected to complement other areas of biology such as genomics, transcriptomics, classical genetics, and chemical genetics in understanding the relationships among genome, gene functions, and living systems.

Original languageEnglish (US)
Pages (from-to)67-79
Number of pages13
JournalMethods in molecular biology (Clifton, N.J.)
Volume577
StatePublished - 2009
Externally publishedYes

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Protein Databases
Systems Biology
Proteomics
Research Personnel
Databases
Information Dissemination
Genomics
Proteins
Genome
Technology
Genes

ASJC Scopus subject areas

  • Medicine(all)

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Human Protein Reference Database and Human Proteinpedia as discovery tools for systems biology. / Prasad, T. S Keshava; Kandasamy, Kumaran; Pandey, Akhilesh.

In: Methods in molecular biology (Clifton, N.J.), Vol. 577, 2009, p. 67-79.

Research output: Contribution to journalArticle

Prasad, T. S Keshava ; Kandasamy, Kumaran ; Pandey, Akhilesh. / Human Protein Reference Database and Human Proteinpedia as discovery tools for systems biology. In: Methods in molecular biology (Clifton, N.J.). 2009 ; Vol. 577. pp. 67-79.
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