TY - JOUR
T1 - Human prenatal exposure to polychlorinated biphenyls (PCBs) and risk behaviors in adolescence
AU - Dickerson, Aisha S.
AU - Ransome, Yusuf
AU - Karlsson, Oskar
N1 - Funding Information:
We thank the CHDS families for their participation in this study. We acknowledge the late Jacob Yerushalmy who had the foresight to design and implement the CHDS; the late Barbara van den Berg, the second Director of the CHDS, whose steadfast allegiance and tireless efforts were responsible for granting the CHDS longevity; Barbara A. Cohn and Lauren Zimmermann for access to the CHDS data and assistance with file preparation. The National Institute of Mental Health Sciences (K01-MH111374, YR), the Swedish Research Council Vetenskapsrådet (OK) and Swedish Research Council Formas (OK) are acknowledged for financial support. Dr. Aisha S. Dickerson was supported in part by a National Institutes of Health training grant T32 ES007069. The authors declare no conflict of interest.
Funding Information:
We thank the CHDS families for their participation in this study. We acknowledge the late Jacob Yerushalmy who had the foresight to design and implement the CHDS; the late Barbara van den Berg, the second Director of the CHDS, whose steadfast allegiance and tireless efforts were responsible for granting the CHDS longevity; Barbara A. Cohn and Lauren Zimmermann for access to the CHDS data and assistance with file preparation. The National Institute of Mental Health Sciences ( K01-MH111374 , YR), the Swedish Research Council Vetenskapsrådet (OK) and Swedish Research Council Formas (OK) are acknowledged for financial support. Dr. Aisha S. Dickerson was supported in part by a National Institutes of Health training grant T32 ES007069. The authors declare no conflict of interest.
Publisher Copyright:
© 2019 The Authors
PY - 2019/8
Y1 - 2019/8
N2 - Polychlorinated biphenyls (PCBs) are chemicals used in a variety of products before they were widely banned due to toxic effects in humans and wildlife. Because of continued persistence and ubiquity of these contaminants, risk of exposure to people living in industrialized countries is still high. Experimental research show that developmental exposure to PCB may alter function of brain pleasure centers and potentially influence disinhibitory behaviors, including tobacco and alcohol use. Yet, the potential effects of developmental PCB exposure on adolescent substance use have not been studied in humans. We used the Child Health and Development Studies (CHDS), a prospective birth cohort study in the Oakland and East Bay areas of California, to investigate associations between prenatal exposure to PCB congeners (66, 74, 99, 118, 138, 153, 170, 180, 187, and 203) and later disinhibitory behaviors in adolescents, specifically alcohol consumption and smoking, in a randomly selected sample (n = 554). Total prenatal PCB exposure was not associated with disinhibitory behaviors, among adolescents. However, the adjusted odds ratio (aOR) for being a current smoker, was higher in subjects within the third quartile of maternal PCB 66 exposure compared to those below the median (aOR = 1.93; 95% CI 1.05, 3.55). The aOR for drinking >2 alcoholic beverages per week, were also higher for adolescents within the third (aOR = 1.46; 95% CI 0.86, 2.47) and fourth quartile of PCB 66 exposure (aOR = 1.39; 95% CI 0.83, 2.35), but the differences did not reach statistical significance. These results suggest that this specific PCB congener may play a role inducing neurodevelopmental alterations that could potentially increase the risk of becoming a long-term user of tobacco and possibly alcohol. There were no notable differences between magnitude or direction of effect between boys and girls. Future replicate analyses with larger longitudinal samples and animal experimental studies of potential underlying mechanisms are warranted.
AB - Polychlorinated biphenyls (PCBs) are chemicals used in a variety of products before they were widely banned due to toxic effects in humans and wildlife. Because of continued persistence and ubiquity of these contaminants, risk of exposure to people living in industrialized countries is still high. Experimental research show that developmental exposure to PCB may alter function of brain pleasure centers and potentially influence disinhibitory behaviors, including tobacco and alcohol use. Yet, the potential effects of developmental PCB exposure on adolescent substance use have not been studied in humans. We used the Child Health and Development Studies (CHDS), a prospective birth cohort study in the Oakland and East Bay areas of California, to investigate associations between prenatal exposure to PCB congeners (66, 74, 99, 118, 138, 153, 170, 180, 187, and 203) and later disinhibitory behaviors in adolescents, specifically alcohol consumption and smoking, in a randomly selected sample (n = 554). Total prenatal PCB exposure was not associated with disinhibitory behaviors, among adolescents. However, the adjusted odds ratio (aOR) for being a current smoker, was higher in subjects within the third quartile of maternal PCB 66 exposure compared to those below the median (aOR = 1.93; 95% CI 1.05, 3.55). The aOR for drinking >2 alcoholic beverages per week, were also higher for adolescents within the third (aOR = 1.46; 95% CI 0.86, 2.47) and fourth quartile of PCB 66 exposure (aOR = 1.39; 95% CI 0.83, 2.35), but the differences did not reach statistical significance. These results suggest that this specific PCB congener may play a role inducing neurodevelopmental alterations that could potentially increase the risk of becoming a long-term user of tobacco and possibly alcohol. There were no notable differences between magnitude or direction of effect between boys and girls. Future replicate analyses with larger longitudinal samples and animal experimental studies of potential underlying mechanisms are warranted.
KW - Alcohol
KW - Endocrine disrupting chemicals
KW - Environmental contaminants
KW - Hormesis
KW - In utero
KW - Polychlorinated biphenyls
KW - Smoking
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UR - http://www.scopus.com/inward/citedby.url?scp=85066086825&partnerID=8YFLogxK
U2 - 10.1016/j.envint.2019.04.051
DO - 10.1016/j.envint.2019.04.051
M3 - Article
C2 - 31146159
AN - SCOPUS:85066086825
VL - 129
SP - 247
EP - 255
JO - Environmental International
JF - Environmental International
SN - 0160-4120
ER -