Human polyomavirus JCV and expression of myelin genes

Jennifer Gordon, Gary L Gallia, Luis Del Valle, Shohreh Amini, Kamel Khalili

Research output: Contribution to journalArticle

Abstract

Myelin basic protein (MBP) is a major component of the myelin sheath of both the central and peripheral nervous systems. A number of neurological diseases in humans are associated with demyelination of the central and/or peripheral nervous systems, including multiple sclerosis and its variants such as acute disseminated encephalomyelitis (AD), acute hemorrhagic leukoencephalopathy, and idiopathic polyneuritis (Guilllame-Barre syndrome), as well as tropical spastic paraparesis (TSP), and progressive multifocal leukoencephalopathy (PML). Multiple sclerosis (MS) is perhaps the most common demyelinating disease and is one of great importance to the clinical neurologist. The underlying cause of the demyelination seen in multiple sclerosis patients is unknown. However, patients frequently have unusually high antibody titers to a number of common viruses, leading to speculation that viral infections may participate in the pathogenesis of MS. On the other hand, studies on maternal and paternal twins have suggested the involvement of genetic factors in the predisposition of an individual toward developing MS. PML, once a rare demyelinating disease of elderly patients with lymphoproliferative disorders, is now a much more common disease affecting patients of all ages due to the increasingly widespread use of immunosuppressive chemotherapy and the prevalence of AIDS. PML is the result of productive infection of oligodendrocytes, the myelin producing cells of the CNS, with the human polyomavirus, JCV. In this article, we have focused our attention on PML, and the role of JCV in disrupting myelin sheaths by affecting myelin basic gene expression, ultimately leading to demyelination.

Original languageEnglish (US)
JournalJournal of NeuroVirology
Volume6
Issue numberSUPPL. 2
StatePublished - 2000
Externally publishedYes

Fingerprint

Polyomavirus
Progressive Multifocal Leukoencephalopathy
Demyelinating Diseases
Myelin Sheath
Multiple Sclerosis
Gene Expression
Peripheral Nervous System
Central Nervous System
Acute Disseminated Encephalomyelitis
Tropical Spastic Paraparesis
Leukoencephalopathies
Neuritis
Myelin Basic Protein
Lymphoproliferative Disorders
Oligodendroglia
Virus Diseases
Immunosuppressive Agents
Rare Diseases
Acquired Immunodeficiency Syndrome
Mothers

Keywords

  • Demyelination
  • Progressive multifocal leukoencephalopathy
  • T-antigen

ASJC Scopus subject areas

  • Virology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Neurology

Cite this

Gordon, J., Gallia, G. L., Del Valle, L., Amini, S., & Khalili, K. (2000). Human polyomavirus JCV and expression of myelin genes. Journal of NeuroVirology, 6(SUPPL. 2).

Human polyomavirus JCV and expression of myelin genes. / Gordon, Jennifer; Gallia, Gary L; Del Valle, Luis; Amini, Shohreh; Khalili, Kamel.

In: Journal of NeuroVirology, Vol. 6, No. SUPPL. 2, 2000.

Research output: Contribution to journalArticle

Gordon, J, Gallia, GL, Del Valle, L, Amini, S & Khalili, K 2000, 'Human polyomavirus JCV and expression of myelin genes', Journal of NeuroVirology, vol. 6, no. SUPPL. 2.
Gordon J, Gallia GL, Del Valle L, Amini S, Khalili K. Human polyomavirus JCV and expression of myelin genes. Journal of NeuroVirology. 2000;6(SUPPL. 2).
Gordon, Jennifer ; Gallia, Gary L ; Del Valle, Luis ; Amini, Shohreh ; Khalili, Kamel. / Human polyomavirus JCV and expression of myelin genes. In: Journal of NeuroVirology. 2000 ; Vol. 6, No. SUPPL. 2.
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