Human polyomavirus 7-associated pruritic rash and viremia in transplant recipients

Jonhan Ho, Jaroslaw J. Jedrych, Huichen Feng, August A. Natalie, Lisa Grandinetti, Ezra Mirvish, Maria M. Crespo, Dhiraj Yadav, Kenneth E. Fasanella, Siobhan Proksell, Shih Fan Kuan, Diana V. Pastrana, Christopher B. Buck, Yoko Shuda, Patrick S. Moore, Yuan Chang

Research output: Contribution to journalArticle

Abstract

Human polyomavirus 7 (HPyV7) is one of 11 HPyVs recently discovered through genomic sequencing technologies. Two lung transplant recipients receiving immunosuppressive therapy developed pruritic, brown plaques on the trunk and extremities showing a distinctive epidermal hyperplasia with virus-laden keratinocytes containing densely packed 36-45-nm icosahedral capsids. Rolling circle amplification and gradient centrifugation testing were positive for encapsidated HPyV7 DNA in skin and peripheral blood specimens from both patients, and HPyV7 early and capsid proteins were abundantly expressed in affected tissues. We describe for the first time that HPyV7 is associated with novel pathogenicity in some immunosuppressed individuals.

Original languageEnglish (US)
Pages (from-to)1560-1565
Number of pages6
JournalJournal of Infectious Diseases
Volume211
Issue number10
DOIs
StatePublished - May 15 2015
Externally publishedYes

Keywords

  • HPyV7
  • Immunosuppression
  • Polyomavirus
  • Skin viral infection
  • Transplantation-associated disease

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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  • Cite this

    Ho, J., Jedrych, J. J., Feng, H., Natalie, A. A., Grandinetti, L., Mirvish, E., Crespo, M. M., Yadav, D., Fasanella, K. E., Proksell, S., Kuan, S. F., Pastrana, D. V., Buck, C. B., Shuda, Y., Moore, P. S., & Chang, Y. (2015). Human polyomavirus 7-associated pruritic rash and viremia in transplant recipients. Journal of Infectious Diseases, 211(10), 1560-1565. https://doi.org/10.1093/infdis/jiu524