Human pathologic correlation with PET in ischemic and nonischemic cardiomyopathy

J. J. Berry, J. M. Hoffman, Charles Jr Steenbergen, J. A. Baker, C. Floyd, P. Van Trigt, M. W. Hanson, R. E. Coleman

Research output: Contribution to journalArticle

Abstract

To assess the correlation between myocardial perfusion, metabolism and histologic findings in patients with cardiomyopathy, we evaluated myocardial perfusion and metabolism using positron emission tomography (PET) with 13NH3 (ammonia) and 18FDG (fluoro-2-deoxy-glucose) in nine patients prior to undergoing orthotopic cardiac transplantation. Four patients had ischemic cardiomyopathy (ISCM) and five had nonischemic cardiomyopathy (NISCM). Normalized circumferential profile analyses of representative mid- ventricular perfusion and metabolism PET images were performed for each patient. A corresponding mid-ventricular transaxial slice was obtained from the formalin fixed explanted heart and processed for routine histology. Hematoxylin-eosin stained and Masson trichrome stained sections were evaluated and the percentage of the slice occupied by infarct was determined planimetrically at 10-degree intervals in a circumferential manner. A significant correlation was found between circumferential normalized PET count density profile of perfusion and metabolism in both the ischemic and nonischemic groups (ISCM range r = 0.65-0.75; NISCM range, r = 0.70-0.87). Furthermore, there was a correlation in the ISCM group between the extent of matched perfusion/metabolism defects and transmural infarct involvement (r = 0.66-0.88). PET perfusion and metabolic data closely correlate with pathologic infarction in human hearts of ischemic cardiomyopathy patients.

Original languageEnglish (US)
Pages (from-to)39-47
Number of pages9
JournalJournal of Nuclear Medicine
Volume34
Issue number1
StatePublished - 1993
Externally publishedYes

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Cardiomyopathies
Positron-Emission Tomography
Perfusion
Fluorodeoxyglucose F18
Heart Transplantation
Hematoxylin
Eosine Yellowish-(YS)
Ammonia
Infarction
Formaldehyde
Histology
Glucose

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Berry, J. J., Hoffman, J. M., Steenbergen, C. J., Baker, J. A., Floyd, C., Van Trigt, P., ... Coleman, R. E. (1993). Human pathologic correlation with PET in ischemic and nonischemic cardiomyopathy. Journal of Nuclear Medicine, 34(1), 39-47.

Human pathologic correlation with PET in ischemic and nonischemic cardiomyopathy. / Berry, J. J.; Hoffman, J. M.; Steenbergen, Charles Jr; Baker, J. A.; Floyd, C.; Van Trigt, P.; Hanson, M. W.; Coleman, R. E.

In: Journal of Nuclear Medicine, Vol. 34, No. 1, 1993, p. 39-47.

Research output: Contribution to journalArticle

Berry, JJ, Hoffman, JM, Steenbergen, CJ, Baker, JA, Floyd, C, Van Trigt, P, Hanson, MW & Coleman, RE 1993, 'Human pathologic correlation with PET in ischemic and nonischemic cardiomyopathy', Journal of Nuclear Medicine, vol. 34, no. 1, pp. 39-47.
Berry, J. J. ; Hoffman, J. M. ; Steenbergen, Charles Jr ; Baker, J. A. ; Floyd, C. ; Van Trigt, P. ; Hanson, M. W. ; Coleman, R. E. / Human pathologic correlation with PET in ischemic and nonischemic cardiomyopathy. In: Journal of Nuclear Medicine. 1993 ; Vol. 34, No. 1. pp. 39-47.
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