Human papillomaviruses in women with a history of abnormal papanicolaou smears and in their male partners

Achim Schneider, Edward Saw Ada, Lutz Gissmann, Keerti Shah

Research output: Contribution to journalArticle

Abstract

Human papillomavirus infection of the genital tract was identified by the filter in situ hybridization test. Exfoliated cervical cells were tested separately for the prevalence of human papillomavirus 6/11 and 16/18. Human papillomavirus deoxyribonucleic acid (DNA) was identified in 70 and 92% of specimens of U.S. and West German women, respectively, who showed concurrent cytologic and colposcopic abnormalities, and in 50 and 54% of women, respectively, who showed neither cytologic nor colposcopic abnormalities at the time of examination. In the cytologic categories of condyloma, mild to moderate dysplasia (cervical intraepithelial neoplasia I/II), and severe dysplasiacarcinoma in situ (cervical intraepithelial neoplasia III), the overall DNA detection rate of human papillomavirus 6/11 and 16/18 varied between 75 and 83%; but human papillomavirus 16/18 was recovered relatively more frequently from the more severe lesions. Forty-eight West German women were monitored cytologically over a period of three to 24 months; progression to carcinoma in situ (cervical intraepithelial neoplasia III) was correlated with initial isolation of human papillomavirus 16/18. The vagina and vestibule were found to be frequent sites of human papillomavirus infection with the same virus type as in the cervix. In an investigation of male partners of 40 human papillomavirus-positive women, human papillomavirus was identified in exfoliated cells from 26; in 19 instances, the males harbored the same human papillomavirus types as their female partners.

Original languageEnglish (US)
Pages (from-to)554-562
Number of pages9
JournalObstetrics and Gynecology
Volume69
Issue number4
StatePublished - 1987

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Papanicolaou Test
Human papillomavirus 16
Cervical Intraepithelial Neoplasia
Human papillomavirus 11
Human papillomavirus 6
Human papillomavirus 18
Papillomavirus Infections
DNA
Carcinoma in Situ
Vagina
Cervix Uteri
In Situ Hybridization
Viruses

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Human papillomaviruses in women with a history of abnormal papanicolaou smears and in their male partners. / Schneider, Achim; Ada, Edward Saw; Gissmann, Lutz; Shah, Keerti.

In: Obstetrics and Gynecology, Vol. 69, No. 4, 1987, p. 554-562.

Research output: Contribution to journalArticle

Schneider, Achim ; Ada, Edward Saw ; Gissmann, Lutz ; Shah, Keerti. / Human papillomaviruses in women with a history of abnormal papanicolaou smears and in their male partners. In: Obstetrics and Gynecology. 1987 ; Vol. 69, No. 4. pp. 554-562.
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