TY - JOUR
T1 - Human Papillomavirus-Related Carcinomas of the Sinonasal Tract
AU - Lopez, Diana C.
AU - Hoke, Austin T.K.
AU - Rooper, Lisa M.
AU - London, Nyall R.
N1 - Funding Information:
This research was supported (in part) by the Intramural Research Program of the NIH, NIDCD. This research was made possible through the NIH Medical Research Scholars Program, a public–private partnership supported jointly by the NIH and contributions to the NIH from the Doris Duke Charitable Foundation (DDCF Grant #2,014,194), the American Association for Dental Research, the Colgate-Palmolive Company, Genentech, Elsevier, and other private donors.
Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2022/9
Y1 - 2022/9
N2 - Purpose of Review: The sinonasal tract is home to a uniquely heterogenous collection of malignant tumors. Human papillomavirus (HPV) has been detected in a number of these, but the virus’ role as an oncogenic driver or coincidental finding remains unclear. We aim to highlight five sinonasal tumor types and synthesize the prevalence, etiologic role, and known clinicopathologic relevance of HPV in each. Recent Findings: The last decade has seen an expansion of investigation into HPV’s oncogenic and prognostic significance within sinonasal malignancies. The sinonasal tract poses challenges to HPV detection where p16 lacks value as an accurate surrogate. A growing body of data supports a potentially favorable clinical profile for certain sinonasal HPV-positive lesions. Summary: HPV represents a potential biologically and clinically relevant factor for some sinonasal malignancies. Definitive conclusions regarding HPV’s role as a potential oncogenic agent require routine testing using validated methodologies, genomic interrogation, and large-scale prospective studies.
AB - Purpose of Review: The sinonasal tract is home to a uniquely heterogenous collection of malignant tumors. Human papillomavirus (HPV) has been detected in a number of these, but the virus’ role as an oncogenic driver or coincidental finding remains unclear. We aim to highlight five sinonasal tumor types and synthesize the prevalence, etiologic role, and known clinicopathologic relevance of HPV in each. Recent Findings: The last decade has seen an expansion of investigation into HPV’s oncogenic and prognostic significance within sinonasal malignancies. The sinonasal tract poses challenges to HPV detection where p16 lacks value as an accurate surrogate. A growing body of data supports a potentially favorable clinical profile for certain sinonasal HPV-positive lesions. Summary: HPV represents a potential biologically and clinically relevant factor for some sinonasal malignancies. Definitive conclusions regarding HPV’s role as a potential oncogenic agent require routine testing using validated methodologies, genomic interrogation, and large-scale prospective studies.
KW - HPV-related multiphenotypic sinonasal carcinoma
KW - Human papillomavirus and sinonasal malignancies
KW - Inverted sinonasal papilloma
KW - Nasopharyngeal carcinoma
KW - Sinonasal squamous cell carcinoma
KW - Sinonasal undifferentiated carcinoma
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U2 - 10.1007/s40136-022-00404-7
DO - 10.1007/s40136-022-00404-7
M3 - Review article
C2 - 36311560
AN - SCOPUS:85129875570
SN - 2167-583X
VL - 10
SP - 291
EP - 302
JO - Current Otorhinolaryngology Reports
JF - Current Otorhinolaryngology Reports
IS - 3
ER -