Human papillomavirus infection of the cervix: Relative risk associations of 15 common anogenital types

A. T. Lorincz, R. Reid, A. B. Jensen, M. D. Greenberg, W. Lancaster, Robert J Kurman

Research output: Contribution to journalArticle

Abstract

During the years 1982-1989, 2627 women were recruited into eight studies analyzing the relationship between human papillomavirus (HPV) infection and cervical neoplasia. Subsequently, each individual was assigned as either a case or control, and each cervical sample was rescreened for HPV DNA by low-stringency Southern blot hybridization. Positive samples were retested at high stringency with specific probes for HPVs 6/11, 16, 18, 31, 33, 35, 42, 43, 44, 45, 51, 52, 56, and (in most instances) 58. Most cases (153 cancers, 261 high-grade and 377 low-grade squamous intraepithelial lesions) had target or cone biopsies; all 270 borderline atypia subjects and more than 85% of the 1566 normal controls had cytology plus colposcopy/cytology. Scientists performing HPV testing were masked to the clinical diagnoses. Human papillomavirus DNA was detected in 79.3% of specimens from women with definite cervical disease (627 of 791), in 23.7% of borderline atypia subjects (64 of 270), and in 6.4% of normal subjects (101 of 1566). Graphic analysis of odds ratios at each point in the diagnostic spectrum defined four categories: 1) 'low risk' (HPVs 6/11, 42, 43, and 44), present in 20.2% (76 of 377) of low-grade lesions but absent in all 153 cancers; 2) 'intermediate risk' (HPVs 31, 33, 35, 51, 52, and 58), detected in 23.8% (62 of 261) of high-grade squamous intraepithelial lesions but only 10.5% (16 of 153) of cancers; 3) 'high risk/HPV 16,' associated with 47.1% of both high-grade intraepithelial lesions (123 of 261) and cancers (72 of 153); and 4) 'high risk/HPV 18' (HPVs 18, 45, and 56), found in 26.8% (41 of 153) of invasive carcinomas but only 6.5% (17 of 261) of high-grade intraepithelial lesions. The presence of an oncogenic HPV type conferred relative risks ranging at 65.1-235.7 for the occurrence of a high-grade lesion and 31.1-296.1 for an invasive cancer.

Original languageEnglish (US)
Pages (from-to)328-337
Number of pages10
JournalObstetrics and Gynecology
Volume79
Issue number3
StatePublished - 1992
Externally publishedYes

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Papillomavirus Infections
Cervix Uteri
Human papillomavirus 11
Human papillomavirus 6
Human papillomavirus 18
Neoplasms
Cell Biology
Human papillomavirus 31
Colposcopy
Human papillomavirus 16
DNA
Southern Blotting
Odds Ratio
Carcinoma
Biopsy

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Lorincz, A. T., Reid, R., Jensen, A. B., Greenberg, M. D., Lancaster, W., & Kurman, R. J. (1992). Human papillomavirus infection of the cervix: Relative risk associations of 15 common anogenital types. Obstetrics and Gynecology, 79(3), 328-337.

Human papillomavirus infection of the cervix : Relative risk associations of 15 common anogenital types. / Lorincz, A. T.; Reid, R.; Jensen, A. B.; Greenberg, M. D.; Lancaster, W.; Kurman, Robert J.

In: Obstetrics and Gynecology, Vol. 79, No. 3, 1992, p. 328-337.

Research output: Contribution to journalArticle

Lorincz, AT, Reid, R, Jensen, AB, Greenberg, MD, Lancaster, W & Kurman, RJ 1992, 'Human papillomavirus infection of the cervix: Relative risk associations of 15 common anogenital types', Obstetrics and Gynecology, vol. 79, no. 3, pp. 328-337.
Lorincz, A. T. ; Reid, R. ; Jensen, A. B. ; Greenberg, M. D. ; Lancaster, W. ; Kurman, Robert J. / Human papillomavirus infection of the cervix : Relative risk associations of 15 common anogenital types. In: Obstetrics and Gynecology. 1992 ; Vol. 79, No. 3. pp. 328-337.
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abstract = "During the years 1982-1989, 2627 women were recruited into eight studies analyzing the relationship between human papillomavirus (HPV) infection and cervical neoplasia. Subsequently, each individual was assigned as either a case or control, and each cervical sample was rescreened for HPV DNA by low-stringency Southern blot hybridization. Positive samples were retested at high stringency with specific probes for HPVs 6/11, 16, 18, 31, 33, 35, 42, 43, 44, 45, 51, 52, 56, and (in most instances) 58. Most cases (153 cancers, 261 high-grade and 377 low-grade squamous intraepithelial lesions) had target or cone biopsies; all 270 borderline atypia subjects and more than 85{\%} of the 1566 normal controls had cytology plus colposcopy/cytology. Scientists performing HPV testing were masked to the clinical diagnoses. Human papillomavirus DNA was detected in 79.3{\%} of specimens from women with definite cervical disease (627 of 791), in 23.7{\%} of borderline atypia subjects (64 of 270), and in 6.4{\%} of normal subjects (101 of 1566). Graphic analysis of odds ratios at each point in the diagnostic spectrum defined four categories: 1) 'low risk' (HPVs 6/11, 42, 43, and 44), present in 20.2{\%} (76 of 377) of low-grade lesions but absent in all 153 cancers; 2) 'intermediate risk' (HPVs 31, 33, 35, 51, 52, and 58), detected in 23.8{\%} (62 of 261) of high-grade squamous intraepithelial lesions but only 10.5{\%} (16 of 153) of cancers; 3) 'high risk/HPV 16,' associated with 47.1{\%} of both high-grade intraepithelial lesions (123 of 261) and cancers (72 of 153); and 4) 'high risk/HPV 18' (HPVs 18, 45, and 56), found in 26.8{\%} (41 of 153) of invasive carcinomas but only 6.5{\%} (17 of 261) of high-grade intraepithelial lesions. The presence of an oncogenic HPV type conferred relative risks ranging at 65.1-235.7 for the occurrence of a high-grade lesion and 31.1-296.1 for an invasive cancer.",
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AU - Lancaster, W.

AU - Kurman, Robert J

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N2 - During the years 1982-1989, 2627 women were recruited into eight studies analyzing the relationship between human papillomavirus (HPV) infection and cervical neoplasia. Subsequently, each individual was assigned as either a case or control, and each cervical sample was rescreened for HPV DNA by low-stringency Southern blot hybridization. Positive samples were retested at high stringency with specific probes for HPVs 6/11, 16, 18, 31, 33, 35, 42, 43, 44, 45, 51, 52, 56, and (in most instances) 58. Most cases (153 cancers, 261 high-grade and 377 low-grade squamous intraepithelial lesions) had target or cone biopsies; all 270 borderline atypia subjects and more than 85% of the 1566 normal controls had cytology plus colposcopy/cytology. Scientists performing HPV testing were masked to the clinical diagnoses. Human papillomavirus DNA was detected in 79.3% of specimens from women with definite cervical disease (627 of 791), in 23.7% of borderline atypia subjects (64 of 270), and in 6.4% of normal subjects (101 of 1566). Graphic analysis of odds ratios at each point in the diagnostic spectrum defined four categories: 1) 'low risk' (HPVs 6/11, 42, 43, and 44), present in 20.2% (76 of 377) of low-grade lesions but absent in all 153 cancers; 2) 'intermediate risk' (HPVs 31, 33, 35, 51, 52, and 58), detected in 23.8% (62 of 261) of high-grade squamous intraepithelial lesions but only 10.5% (16 of 153) of cancers; 3) 'high risk/HPV 16,' associated with 47.1% of both high-grade intraepithelial lesions (123 of 261) and cancers (72 of 153); and 4) 'high risk/HPV 18' (HPVs 18, 45, and 56), found in 26.8% (41 of 153) of invasive carcinomas but only 6.5% (17 of 261) of high-grade intraepithelial lesions. The presence of an oncogenic HPV type conferred relative risks ranging at 65.1-235.7 for the occurrence of a high-grade lesion and 31.1-296.1 for an invasive cancer.

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