Human papillomavirus infection and oral cancer: A case-control study in Montreal, Canada

Javier Pintos, Martin J. Black, Nader Sadeghi, Parviz Ghadirian, Anthony G. Zeitouni, Raphael P Viscidi, Rolando Herrero, François Coutlée, Eduardo L. Franco

Research output: Contribution to journalArticle

Abstract

The objective of the present study was to examine the association between human papillomavirus (HPV) infection and risk of developing oral cancer. The investigation followed a hospital-based case-control design. Cases consisted of newly diagnosed patients with squamous cell carcinoma of the oral cavity and oropharynx. Controls were frequency matched to cases on gender, age, and hospital. Subjects were interviewed to elicit information on putative risk factors. Oral exfoliated cells were tested for detection of HPV DNA by the PGMY09/11 polymerase chain reaction protocol. Serum antibodies against HPV 16, 18, and 31 viral capsids were detected using an immunoassay technique. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CI) of oral cancer according to HPV exposure variables. HPV DNA was detected in 19% of cases (14 out of 72), and 5% of controls (six out of 129). Among tonsil-related cancers (palatine tonsil and base of tongue) viral DNA was detected in 43% of cases (nine out of 21). The OR for tonsil-related cancers for high-risk HPV types was 19.32 (95%CI: 2.3-159.5), after adjustment for socio-demographic characteristics, tobacco, and alcohol consumption. The equivalent OR for HPV 16 seropositivity was 31.51 (95%CI: 4.5-219.7). The ORs of non-tonsillar oral cancers for high risk HPV DNA in oral cells and for seropositivity were 2.14 (95%CI: 0.4-13.0) and 3.16 (95%CI: 0.8-13.0), respectively. These results provide evidence supporting a strong causal association between HPV infection and tonsil-related cancers. The evidence for an etiologic link is less clear for non-tonsillar oral cancers.

Original languageEnglish (US)
Pages (from-to)242-250
Number of pages9
JournalOral Oncology
Volume44
Issue number3
DOIs
StatePublished - Mar 2008

Fingerprint

Papillomavirus Infections
Mouth Neoplasms
Tonsillar Neoplasms
Canada
Case-Control Studies
Confidence Intervals
Odds Ratio
Human papillomavirus 16
DNA
Human papillomavirus 31
Human papillomavirus 18
Oropharynx
Capsid
Palatine Tonsil
Viral DNA
Tobacco Use
Immunoassay
Tongue
Alcohol Drinking
Mouth

Keywords

  • Human papillomavirus
  • Oral cancer
  • Oral neoplasms
  • Serology
  • Tonsillar cancers

ASJC Scopus subject areas

  • Oncology

Cite this

Pintos, J., Black, M. J., Sadeghi, N., Ghadirian, P., Zeitouni, A. G., Viscidi, R. P., ... Franco, E. L. (2008). Human papillomavirus infection and oral cancer: A case-control study in Montreal, Canada. Oral Oncology, 44(3), 242-250. https://doi.org/10.1016/j.oraloncology.2007.02.005

Human papillomavirus infection and oral cancer : A case-control study in Montreal, Canada. / Pintos, Javier; Black, Martin J.; Sadeghi, Nader; Ghadirian, Parviz; Zeitouni, Anthony G.; Viscidi, Raphael P; Herrero, Rolando; Coutlée, François; Franco, Eduardo L.

In: Oral Oncology, Vol. 44, No. 3, 03.2008, p. 242-250.

Research output: Contribution to journalArticle

Pintos, J, Black, MJ, Sadeghi, N, Ghadirian, P, Zeitouni, AG, Viscidi, RP, Herrero, R, Coutlée, F & Franco, EL 2008, 'Human papillomavirus infection and oral cancer: A case-control study in Montreal, Canada', Oral Oncology, vol. 44, no. 3, pp. 242-250. https://doi.org/10.1016/j.oraloncology.2007.02.005
Pintos, Javier ; Black, Martin J. ; Sadeghi, Nader ; Ghadirian, Parviz ; Zeitouni, Anthony G. ; Viscidi, Raphael P ; Herrero, Rolando ; Coutlée, François ; Franco, Eduardo L. / Human papillomavirus infection and oral cancer : A case-control study in Montreal, Canada. In: Oral Oncology. 2008 ; Vol. 44, No. 3. pp. 242-250.
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