TY - JOUR
T1 - Human papillomavirus infection and cervical cytology in women screened for cervical cancer in the United States, 2003-2005
AU - Datta, S. Deblina
AU - Koutsky, Laura A.
AU - Ratelle, Sylvie
AU - Unger, Elizabeth R.
AU - Shlay, Judith
AU - McClain, Tracie
AU - Weaver, Beth
AU - Kerndt, Peter
AU - Zenilman, Jonathan
AU - Hagensee, Michael
AU - Suhr, Cristen J.
AU - Weinstock, Hillard
PY - 2008/4/1
Y1 - 2008/4/1
N2 - Background: Millions of women in the United States receive cervical screening in sexually transmitted disease (STD), family planning, and primary care clinical settings. Objective: To inform current cervical screening programs. Design: Measurement of abnormal Papanicolaou (Pap) tests and high-risk human papillomavirus (HPV) infection among demographically diverse women who received routine cervical screening from January 2003 to December 2005 in the United States. Setting: 26 STD, family planning, and primary care clinics in 6 U.S. cities. Patients: 9657 women age 14 to 65 years receiving routine cervical screening. Measurements: Pap test results and high-risk HPV prevalence by Hybrid Capture 2 assay (Digene, Gaithersburg, Maryland). Results: Among 9657 patients, overall high-risk HPV prevalence by Hybrid Capture 2 testing was 23% (95% CI, 22% to 24%). Prevalence was highest among women age 14 to 19 years (35% [CI, 32% to 38%]) and lowest among women age 50 to 65 years (6% [CI, 4% to 8%]). Prevalence by clinic type (adjusted for age and city) ranged from 26% (CI, 24% to 29%) in STD clinics to 17% (CI, 16% to 20%) in primary care clinics. Women younger than 30 years of age whose Pap test showed atypical squamous cells of undetermined significance had a high-risk HPV prevalence of 53%; women 30 years of age or older with normal Pap tests had a 9% prevalence. Values did not vary substantially by clinic type. Limitation: Hybrid Capture 2 and Pap testing were noncentralized, and consent was required for enrollment. Conclusion: High-risk HPV was widespread among women receiving cervical screening in the United States. Many women 30 years of age or older with normal Pap tests would need follow-up if Hybrid Capture 2 testing is added to cytology screening.
AB - Background: Millions of women in the United States receive cervical screening in sexually transmitted disease (STD), family planning, and primary care clinical settings. Objective: To inform current cervical screening programs. Design: Measurement of abnormal Papanicolaou (Pap) tests and high-risk human papillomavirus (HPV) infection among demographically diverse women who received routine cervical screening from January 2003 to December 2005 in the United States. Setting: 26 STD, family planning, and primary care clinics in 6 U.S. cities. Patients: 9657 women age 14 to 65 years receiving routine cervical screening. Measurements: Pap test results and high-risk HPV prevalence by Hybrid Capture 2 assay (Digene, Gaithersburg, Maryland). Results: Among 9657 patients, overall high-risk HPV prevalence by Hybrid Capture 2 testing was 23% (95% CI, 22% to 24%). Prevalence was highest among women age 14 to 19 years (35% [CI, 32% to 38%]) and lowest among women age 50 to 65 years (6% [CI, 4% to 8%]). Prevalence by clinic type (adjusted for age and city) ranged from 26% (CI, 24% to 29%) in STD clinics to 17% (CI, 16% to 20%) in primary care clinics. Women younger than 30 years of age whose Pap test showed atypical squamous cells of undetermined significance had a high-risk HPV prevalence of 53%; women 30 years of age or older with normal Pap tests had a 9% prevalence. Values did not vary substantially by clinic type. Limitation: Hybrid Capture 2 and Pap testing were noncentralized, and consent was required for enrollment. Conclusion: High-risk HPV was widespread among women receiving cervical screening in the United States. Many women 30 years of age or older with normal Pap tests would need follow-up if Hybrid Capture 2 testing is added to cytology screening.
UR - http://www.scopus.com/inward/record.url?scp=42249084911&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=42249084911&partnerID=8YFLogxK
U2 - 10.7326/0003-4819-148-7-200804010-00004
DO - 10.7326/0003-4819-148-7-200804010-00004
M3 - Article
C2 - 18378945
AN - SCOPUS:42249084911
SN - 0003-4819
VL - 148
SP - 493
EP - 500
JO - Annals of internal medicine
JF - Annals of internal medicine
IS - 7
ER -