TY - JOUR
T1 - Human papillomavirus in women with and without HIV-1 infection attending an STI clinic in Vitoria, Brazil
AU - Coelho Lima, Bettina Moulin
AU - Golub, Jonathan E.
AU - Tonani Mattos, Adriana
AU - Bueno De Freitas, Luciana
AU - Cruz Spano, Liliana
AU - Espinosa Miranda, Angélica
PY - 2009/9
Y1 - 2009/9
N2 - We conducted a cross-sectional study in Vitória, Brazil, to assess the prevalence of human papillomavirus (HPV) infection in HIV-positive and HIV-negative women attending a sexually transmitted infection (STI)/AIDS clinic. We also investigated the presence of HPV genotypes and assessed covariates for HIV infection. Enrolled patients received a gynecological evaluation, and cervical scrape samples were collected for cytological analysis and HPV-DNA polymerase chain reaction (PCR). A blood sample was obtained to determine HIV status. HPV infection and squamous intraepithelial lesions were studied in 284 women, 112 (39.4%) HIV-positive women and 172 (60.5%) HIV-negative women. HPV-DNA was detected in 133 (46.8%). HIV-infected women were almost twice as likely to be concurrently infected with HPV than HIV-negative women (OR = 1.87 95% CI: 1.16-3.03). The high proportion of HPV detected among women attending an STI/AIDS clinic, particularly among HIV-infected women, proves the importance of screening this high-risk group in the hope of earlier detection and treatment of cervical intraepithelial neoplasia (CIN).
AB - We conducted a cross-sectional study in Vitória, Brazil, to assess the prevalence of human papillomavirus (HPV) infection in HIV-positive and HIV-negative women attending a sexually transmitted infection (STI)/AIDS clinic. We also investigated the presence of HPV genotypes and assessed covariates for HIV infection. Enrolled patients received a gynecological evaluation, and cervical scrape samples were collected for cytological analysis and HPV-DNA polymerase chain reaction (PCR). A blood sample was obtained to determine HIV status. HPV infection and squamous intraepithelial lesions were studied in 284 women, 112 (39.4%) HIV-positive women and 172 (60.5%) HIV-negative women. HPV-DNA was detected in 133 (46.8%). HIV-infected women were almost twice as likely to be concurrently infected with HPV than HIV-negative women (OR = 1.87 95% CI: 1.16-3.03). The high proportion of HPV detected among women attending an STI/AIDS clinic, particularly among HIV-infected women, proves the importance of screening this high-risk group in the hope of earlier detection and treatment of cervical intraepithelial neoplasia (CIN).
KW - Brazil
KW - HIV
KW - cervical intraepitial neoplasia (CIN)
KW - human papillomavirus (HPV)
KW - sexually transmitted infection (STI) clinic
KW - women
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UR - http://www.scopus.com/inward/citedby.url?scp=75349102522&partnerID=8YFLogxK
U2 - 10.1177/1545109709341855
DO - 10.1177/1545109709341855
M3 - Article
C2 - 19721099
AN - SCOPUS:75349102522
SN - 1545-1097
VL - 8
SP - 286
EP - 290
JO - Journal of the International Association of Physicians in AIDS Care
JF - Journal of the International Association of Physicians in AIDS Care
IS - 5
ER -