Human Papillomavirus (HPV) 6, 11, 16, and 18 seroprevalence is associated with sexual practice and age: Results from the multinational HPV infection in men study (HIM study)

Beibei Lu, Raphael P Viscidi, Ji Hyun Lee, Yougui Wu, Luisa L. Villa, Eduardo Lazcano-Ponce, Roberto J. Carvalho Da Silva, Maria Luiza Baggio, Manuel Quiterio, Jorge Salmerón, Danelle C. Smith, Martha Abrahamsen, Mary Papenfuss, Heather G. Stockwell, Anna R. Giuliano

Research output: Contribution to journalArticle

Abstract

Background: Few human papillomavirus (HPV) serology studies have evaluated type-specific seroprevalence of vaccine HPV types in men. This study investigates seroprevalence of HPV 6, 11, 16, and 18, and associated risk factors in men residing in three countries (United States, Mexico, and Brazil). Methods: Data from 1,477 men aged 18 to 70 enrolled in the HPV Infection in Men Study (HIM Study) were analyzed. Serum antibody testing was performed with virus-like particle-based ELISA. Potential risk factors were assessed for individual HPV types by the use of logistic regression. Results: Overall, HPV-6, 11, 16, and 18 seroprevalence was 14.8%, 17.3%, 11.2%, and 5.8%, respectively. Thirty-four percent of men were seropositive to one or more HPV types. When examined by sexual practice, 31.2% of men who had sex with women, 65.6% of men who had sex with men (MSM), and 59.4% of men who had sex with both men and women (MSMW) were seropositive to one or more HPV types. Seroprevalence increased with age among young-to-middle-aged men with significant upward age trends observed for HPV 11, 16, and 18. Men with multiple lifetime male anal sex partners were 2 to 4 times more likely to be HPV 6 or 11 seropositive and 3 to 11 times more likely to be HPV 16 or 18 seropositive. Conclusion: Our data indicate that exposures to vaccine HPV types were common in men and highly prevalent among MSM and MSMW. Impact: Our study provides strong evidence that the practice of same-sex anal intercourse is an independent risk factor for seroprevalence of individual vaccine HPV types. Examination of antibody responses to HPV infections at various anatomic sites in future studies is needed to elaborate on the mechanism.

Original languageEnglish (US)
Pages (from-to)990-1002
Number of pages13
JournalCancer Epidemiology Biomarkers and Prevention
Volume20
Issue number5
DOIs
StatePublished - May 2011

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Human papillomavirus 11
Human papillomavirus 6
Papillomavirus Infections
Seroepidemiologic Studies
Papillomavirus Vaccines
Human papillomavirus 18
Human papillomavirus 16
Sexual Behavior
Serology
Mexico
Virion
Antibody Formation

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Human Papillomavirus (HPV) 6, 11, 16, and 18 seroprevalence is associated with sexual practice and age : Results from the multinational HPV infection in men study (HIM study). / Lu, Beibei; Viscidi, Raphael P; Lee, Ji Hyun; Wu, Yougui; Villa, Luisa L.; Lazcano-Ponce, Eduardo; Carvalho Da Silva, Roberto J.; Baggio, Maria Luiza; Quiterio, Manuel; Salmerón, Jorge; Smith, Danelle C.; Abrahamsen, Martha; Papenfuss, Mary; Stockwell, Heather G.; Giuliano, Anna R.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 20, No. 5, 05.2011, p. 990-1002.

Research output: Contribution to journalArticle

Lu, B, Viscidi, RP, Lee, JH, Wu, Y, Villa, LL, Lazcano-Ponce, E, Carvalho Da Silva, RJ, Baggio, ML, Quiterio, M, Salmerón, J, Smith, DC, Abrahamsen, M, Papenfuss, M, Stockwell, HG & Giuliano, AR 2011, 'Human Papillomavirus (HPV) 6, 11, 16, and 18 seroprevalence is associated with sexual practice and age: Results from the multinational HPV infection in men study (HIM study)', Cancer Epidemiology Biomarkers and Prevention, vol. 20, no. 5, pp. 990-1002. https://doi.org/10.1158/1055-9965.EPI-10-1160
Lu, Beibei ; Viscidi, Raphael P ; Lee, Ji Hyun ; Wu, Yougui ; Villa, Luisa L. ; Lazcano-Ponce, Eduardo ; Carvalho Da Silva, Roberto J. ; Baggio, Maria Luiza ; Quiterio, Manuel ; Salmerón, Jorge ; Smith, Danelle C. ; Abrahamsen, Martha ; Papenfuss, Mary ; Stockwell, Heather G. ; Giuliano, Anna R. / Human Papillomavirus (HPV) 6, 11, 16, and 18 seroprevalence is associated with sexual practice and age : Results from the multinational HPV infection in men study (HIM study). In: Cancer Epidemiology Biomarkers and Prevention. 2011 ; Vol. 20, No. 5. pp. 990-1002.
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abstract = "Background: Few human papillomavirus (HPV) serology studies have evaluated type-specific seroprevalence of vaccine HPV types in men. This study investigates seroprevalence of HPV 6, 11, 16, and 18, and associated risk factors in men residing in three countries (United States, Mexico, and Brazil). Methods: Data from 1,477 men aged 18 to 70 enrolled in the HPV Infection in Men Study (HIM Study) were analyzed. Serum antibody testing was performed with virus-like particle-based ELISA. Potential risk factors were assessed for individual HPV types by the use of logistic regression. Results: Overall, HPV-6, 11, 16, and 18 seroprevalence was 14.8{\%}, 17.3{\%}, 11.2{\%}, and 5.8{\%}, respectively. Thirty-four percent of men were seropositive to one or more HPV types. When examined by sexual practice, 31.2{\%} of men who had sex with women, 65.6{\%} of men who had sex with men (MSM), and 59.4{\%} of men who had sex with both men and women (MSMW) were seropositive to one or more HPV types. Seroprevalence increased with age among young-to-middle-aged men with significant upward age trends observed for HPV 11, 16, and 18. Men with multiple lifetime male anal sex partners were 2 to 4 times more likely to be HPV 6 or 11 seropositive and 3 to 11 times more likely to be HPV 16 or 18 seropositive. Conclusion: Our data indicate that exposures to vaccine HPV types were common in men and highly prevalent among MSM and MSMW. Impact: Our study provides strong evidence that the practice of same-sex anal intercourse is an independent risk factor for seroprevalence of individual vaccine HPV types. Examination of antibody responses to HPV infections at various anatomic sites in future studies is needed to elaborate on the mechanism.",
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T1 - Human Papillomavirus (HPV) 6, 11, 16, and 18 seroprevalence is associated with sexual practice and age

T2 - Results from the multinational HPV infection in men study (HIM study)

AU - Lu, Beibei

AU - Viscidi, Raphael P

AU - Lee, Ji Hyun

AU - Wu, Yougui

AU - Villa, Luisa L.

AU - Lazcano-Ponce, Eduardo

AU - Carvalho Da Silva, Roberto J.

AU - Baggio, Maria Luiza

AU - Quiterio, Manuel

AU - Salmerón, Jorge

AU - Smith, Danelle C.

AU - Abrahamsen, Martha

AU - Papenfuss, Mary

AU - Stockwell, Heather G.

AU - Giuliano, Anna R.

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N2 - Background: Few human papillomavirus (HPV) serology studies have evaluated type-specific seroprevalence of vaccine HPV types in men. This study investigates seroprevalence of HPV 6, 11, 16, and 18, and associated risk factors in men residing in three countries (United States, Mexico, and Brazil). Methods: Data from 1,477 men aged 18 to 70 enrolled in the HPV Infection in Men Study (HIM Study) were analyzed. Serum antibody testing was performed with virus-like particle-based ELISA. Potential risk factors were assessed for individual HPV types by the use of logistic regression. Results: Overall, HPV-6, 11, 16, and 18 seroprevalence was 14.8%, 17.3%, 11.2%, and 5.8%, respectively. Thirty-four percent of men were seropositive to one or more HPV types. When examined by sexual practice, 31.2% of men who had sex with women, 65.6% of men who had sex with men (MSM), and 59.4% of men who had sex with both men and women (MSMW) were seropositive to one or more HPV types. Seroprevalence increased with age among young-to-middle-aged men with significant upward age trends observed for HPV 11, 16, and 18. Men with multiple lifetime male anal sex partners were 2 to 4 times more likely to be HPV 6 or 11 seropositive and 3 to 11 times more likely to be HPV 16 or 18 seropositive. Conclusion: Our data indicate that exposures to vaccine HPV types were common in men and highly prevalent among MSM and MSMW. Impact: Our study provides strong evidence that the practice of same-sex anal intercourse is an independent risk factor for seroprevalence of individual vaccine HPV types. Examination of antibody responses to HPV infections at various anatomic sites in future studies is needed to elaborate on the mechanism.

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