Human papillomavirus deoxyribonucleic acid in cervical carcinoma from primary and metastatic sites

Wayne D. Lancaster, Carlos Castellano, Carlos Santos, Gregorio Delgado, Robert J. Kurman, A. Bennett Jenson

Research output: Contribution to journalArticlepeer-review

Abstract

Tissue from 13 cervical cancers and pelvic or para-aortic lymph nodes from the same patient were evaluated by deoxyribonucleic acid hybridization with a human papillomavirus type 16 deoxyribonucleic acid probe for the presence of human papillomavirus-related deoxyribonucleic acid sequences. Twelve of the primary malignancies were squamous cancers and one was an adenocarcinoma. Eight of the primary tumors contained human papillomavirus type 16 deoxyribonucleic acid sequences, and five contained viral sequences closely related to human papillomavirus type 16. Histopathologic diagnosis confirmed malignant cells in six of 13 lymph nodes; three of these specimens contained human papillomavirus type 16 sequences while three had human papillomavirus type 16-related sequences. One lymph node that failed to show malignant cells also contained human papillomavirus type 16 deoxyribonucleic acid. The remaining lymph nodes did not contain malignant cells by either histologic examination or deoxyribonucleic acid hybridization. The human papillomavirus deoxyribonucleic acid sequences in the lymph nodes were similar to those in the matched primary cancer in all cases. These data provide further evidence implicating human papillomavirus in the etiology of cervical cancer.

Original languageEnglish (US)
Pages (from-to)115-119
Number of pages5
JournalAmerican journal of obstetrics and gynecology
Volume154
Issue number1
DOIs
StatePublished - Jan 1986
Externally publishedYes

Keywords

  • Human papillomavirus
  • cervical cancer
  • metastases

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Fingerprint Dive into the research topics of 'Human papillomavirus deoxyribonucleic acid in cervical carcinoma from primary and metastatic sites'. Together they form a unique fingerprint.

Cite this