Human papillomavirus and cervical neoplasia: A case-control study in Taiwan

K. L. Liaw, A. W. Hsing, C. J. Chen, M. H. Schiffman, T. Y. Zhang, C. Y. Hsieh, C. E. Greer, S. L. You, T. W. Huang, Tzyy Choou Wu, T. J. O'Leary, J. D. Seidman, W. J. Blot, Curtis L Meinert, M. M. Manos

Research output: Contribution to journalArticle

Abstract

As part of a large-scale, community-based cervical neoplasia screening project in rural Taiwan, a case-control study was undertaken to evaluate the etiologic role of human papillomavirus (HPV) infection in this mainly monogamous (2% reported having multiple sexual partners) female population. A total of 88 biopsy-confirmed cases and 261 cytologically normal controls were selected for the study. The case group included 40 cases of cervical intraepithelial neoplasia (CIN) 1, 9 CIN 2, 36 of CIN 3 and 3 cases of invasive cancer. Cervical swabs collected at screening from study subjects were tested for HPV DNA by an L1 consensus primer polymerase chain reaction (PCR)-based technique. HPV DNA was found in 92% of high-grade cases (CIN 2-3 and invasive cancer); 54% of low-grade cases (CIN 1); and 9% of controls. HPV was significantly associated with both high-grade and low-grade cervical neoplasia. As reported in Western countries, HPV 16 was the predominant type among HPV-positive ligh-grade cases. However, HPVs 52 and/or 58 combined were the most common types among HPV-positive low-grade cases and controls. Among women without any high-risk HPV infection (types 16, 18, 31 or 45), those with multiple-type HPV infection had a higher risk for high-grade cervical neoplasia than those with single-type infection. Overall, 91% of high-grade cases and 50% of low-grade cases could be attributed to HPV infection. Our results show that, even in this monogamous population, HPV is the major risk factor for high-grade cervical neoplasia.

Original languageEnglish (US)
Pages (from-to)565-571
Number of pages7
JournalInternational Journal of Cancer
Volume62
Issue number5
DOIs
StatePublished - 1995

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Taiwan
Case-Control Studies
Cervical Intraepithelial Neoplasia
Papillomavirus Infections
Neoplasms
Human papillomavirus 16
Sexual Partners
DNA
Population
Biopsy
Polymerase Chain Reaction
Infection

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Liaw, K. L., Hsing, A. W., Chen, C. J., Schiffman, M. H., Zhang, T. Y., Hsieh, C. Y., ... Manos, M. M. (1995). Human papillomavirus and cervical neoplasia: A case-control study in Taiwan. International Journal of Cancer, 62(5), 565-571. https://doi.org/10.1002/ijc.2910620513

Human papillomavirus and cervical neoplasia : A case-control study in Taiwan. / Liaw, K. L.; Hsing, A. W.; Chen, C. J.; Schiffman, M. H.; Zhang, T. Y.; Hsieh, C. Y.; Greer, C. E.; You, S. L.; Huang, T. W.; Wu, Tzyy Choou; O'Leary, T. J.; Seidman, J. D.; Blot, W. J.; Meinert, Curtis L; Manos, M. M.

In: International Journal of Cancer, Vol. 62, No. 5, 1995, p. 565-571.

Research output: Contribution to journalArticle

Liaw, KL, Hsing, AW, Chen, CJ, Schiffman, MH, Zhang, TY, Hsieh, CY, Greer, CE, You, SL, Huang, TW, Wu, TC, O'Leary, TJ, Seidman, JD, Blot, WJ, Meinert, CL & Manos, MM 1995, 'Human papillomavirus and cervical neoplasia: A case-control study in Taiwan', International Journal of Cancer, vol. 62, no. 5, pp. 565-571. https://doi.org/10.1002/ijc.2910620513
Liaw, K. L. ; Hsing, A. W. ; Chen, C. J. ; Schiffman, M. H. ; Zhang, T. Y. ; Hsieh, C. Y. ; Greer, C. E. ; You, S. L. ; Huang, T. W. ; Wu, Tzyy Choou ; O'Leary, T. J. ; Seidman, J. D. ; Blot, W. J. ; Meinert, Curtis L ; Manos, M. M. / Human papillomavirus and cervical neoplasia : A case-control study in Taiwan. In: International Journal of Cancer. 1995 ; Vol. 62, No. 5. pp. 565-571.
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title = "Human papillomavirus and cervical neoplasia: A case-control study in Taiwan",
abstract = "As part of a large-scale, community-based cervical neoplasia screening project in rural Taiwan, a case-control study was undertaken to evaluate the etiologic role of human papillomavirus (HPV) infection in this mainly monogamous (2{\%} reported having multiple sexual partners) female population. A total of 88 biopsy-confirmed cases and 261 cytologically normal controls were selected for the study. The case group included 40 cases of cervical intraepithelial neoplasia (CIN) 1, 9 CIN 2, 36 of CIN 3 and 3 cases of invasive cancer. Cervical swabs collected at screening from study subjects were tested for HPV DNA by an L1 consensus primer polymerase chain reaction (PCR)-based technique. HPV DNA was found in 92{\%} of high-grade cases (CIN 2-3 and invasive cancer); 54{\%} of low-grade cases (CIN 1); and 9{\%} of controls. HPV was significantly associated with both high-grade and low-grade cervical neoplasia. As reported in Western countries, HPV 16 was the predominant type among HPV-positive ligh-grade cases. However, HPVs 52 and/or 58 combined were the most common types among HPV-positive low-grade cases and controls. Among women without any high-risk HPV infection (types 16, 18, 31 or 45), those with multiple-type HPV infection had a higher risk for high-grade cervical neoplasia than those with single-type infection. Overall, 91{\%} of high-grade cases and 50{\%} of low-grade cases could be attributed to HPV infection. Our results show that, even in this monogamous population, HPV is the major risk factor for high-grade cervical neoplasia.",
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AU - O'Leary, T. J.

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