Abstract
Introduction: We studied the role of human papillomavirus (HPV) typing in predicting cervical dysplasia in women with abnormal Papanicolaou (Pap) test results. Study Design/Methods: A university colposcopy clinic-based consecutive sample of 179 women completed a questionnaire and underwent colposcopy, HPV typing (Hybrid Capture System HPV DNA Assay II; Digene Diagnostics, Gaithersburg, MD, USA), and biopsy (if indicated). Results: No severe dysplasia was observed in women with low-risk HPV or in women with negative HPV test results who had a low-grade abnormality on the Pap test. High-risk (HR) HPV was present in every case of severe dysplasia on biopsy. The cumulative odds risk for cervical dysplasia was 1.11 in HIV(+) women with low-grade squamous intraepithelial lesion on the Pap test who were older than 21 years of age and HPV-HR(+). Conclusions: In the population studied, HPV typing is a valuable adjunct to a low-grade abnormality on the Pap test in predicting the absence of cervical dysplasia on biopsy. Larger prospective population-based studies are needed to study the role of HPV as a negative predictor of disease in cervical dysplasia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 283-287 |
| Number of pages | 5 |
| Journal | Journal of Human Virology |
| Volume | 4 |
| Issue number | 5 |
| State | Published - 2001 |
| Externally published | Yes |
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Keywords
- Abnormal Papanicolaou test
- Age
- HIV cervical dysplasia
- HPV
ASJC Scopus subject areas
- Virology
Cite this
Human papillomavirus absence predicts normal cervical histopathologic findings with abnormal papanicolaou smears : A study of a university-based inner city population. / Khanna, Niharika; Brooks, Sandra E.; Chen, T. Timothy; Simsir, Aylin; Gordon, Nancy J.; Taylor, Gregory.
In: Journal of Human Virology, Vol. 4, No. 5, 2001, p. 283-287.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Human papillomavirus absence predicts normal cervical histopathologic findings with abnormal papanicolaou smears
T2 - A study of a university-based inner city population
AU - Khanna, Niharika
AU - Brooks, Sandra E.
AU - Chen, T. Timothy
AU - Simsir, Aylin
AU - Gordon, Nancy J.
AU - Taylor, Gregory
PY - 2001
Y1 - 2001
N2 - Introduction: We studied the role of human papillomavirus (HPV) typing in predicting cervical dysplasia in women with abnormal Papanicolaou (Pap) test results. Study Design/Methods: A university colposcopy clinic-based consecutive sample of 179 women completed a questionnaire and underwent colposcopy, HPV typing (Hybrid Capture System HPV DNA Assay II; Digene Diagnostics, Gaithersburg, MD, USA), and biopsy (if indicated). Results: No severe dysplasia was observed in women with low-risk HPV or in women with negative HPV test results who had a low-grade abnormality on the Pap test. High-risk (HR) HPV was present in every case of severe dysplasia on biopsy. The cumulative odds risk for cervical dysplasia was 1.11 in HIV(+) women with low-grade squamous intraepithelial lesion on the Pap test who were older than 21 years of age and HPV-HR(+). Conclusions: In the population studied, HPV typing is a valuable adjunct to a low-grade abnormality on the Pap test in predicting the absence of cervical dysplasia on biopsy. Larger prospective population-based studies are needed to study the role of HPV as a negative predictor of disease in cervical dysplasia.
AB - Introduction: We studied the role of human papillomavirus (HPV) typing in predicting cervical dysplasia in women with abnormal Papanicolaou (Pap) test results. Study Design/Methods: A university colposcopy clinic-based consecutive sample of 179 women completed a questionnaire and underwent colposcopy, HPV typing (Hybrid Capture System HPV DNA Assay II; Digene Diagnostics, Gaithersburg, MD, USA), and biopsy (if indicated). Results: No severe dysplasia was observed in women with low-risk HPV or in women with negative HPV test results who had a low-grade abnormality on the Pap test. High-risk (HR) HPV was present in every case of severe dysplasia on biopsy. The cumulative odds risk for cervical dysplasia was 1.11 in HIV(+) women with low-grade squamous intraepithelial lesion on the Pap test who were older than 21 years of age and HPV-HR(+). Conclusions: In the population studied, HPV typing is a valuable adjunct to a low-grade abnormality on the Pap test in predicting the absence of cervical dysplasia on biopsy. Larger prospective population-based studies are needed to study the role of HPV as a negative predictor of disease in cervical dysplasia.
KW - Abnormal Papanicolaou test
KW - Age
KW - HIV cervical dysplasia
KW - HPV
UR - http://www.scopus.com/inward/record.url?scp=0035729770&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035729770&partnerID=8YFLogxK
M3 - Article
C2 - 11907386
AN - SCOPUS:0035729770
VL - 4
SP - 283
EP - 287
JO - Journal of Human Virology
JF - Journal of Human Virology
SN - 1090-9508
IS - 5
ER -