Abstract
Introduction: We studied the role of human papillomavirus (HPV) typing in predicting cervical dysplasia in women with abnormal Papanicolaou (Pap) test results. Study Design/Methods: A university colposcopy clinic-based consecutive sample of 179 women completed a questionnaire and underwent colposcopy, HPV typing (Hybrid Capture System HPV DNA Assay II; Digene Diagnostics, Gaithersburg, MD, USA), and biopsy (if indicated). Results: No severe dysplasia was observed in women with low-risk HPV or in women with negative HPV test results who had a low-grade abnormality on the Pap test. High-risk (HR) HPV was present in every case of severe dysplasia on biopsy. The cumulative odds risk for cervical dysplasia was 1.11 in HIV(+) women with low-grade squamous intraepithelial lesion on the Pap test who were older than 21 years of age and HPV-HR(+). Conclusions: In the population studied, HPV typing is a valuable adjunct to a low-grade abnormality on the Pap test in predicting the absence of cervical dysplasia on biopsy. Larger prospective population-based studies are needed to study the role of HPV as a negative predictor of disease in cervical dysplasia.
Original language | English (US) |
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Pages (from-to) | 283-287 |
Number of pages | 5 |
Journal | Journal of Human Virology |
Volume | 4 |
Issue number | 5 |
State | Published - 2001 |
Externally published | Yes |
Keywords
- Abnormal Papanicolaou test
- Age
- HIV cervical dysplasia
- HPV
ASJC Scopus subject areas
- Virology