Human metapneumovirus infection plays an etiologic role in acute asthma exacerbations requiring hospitalization in adults

John V. Williams, James E. Crowe, Rachel Enriquez, Patricia Minton, R. Stokes Peebles, Robert G. Hamilton, Stanley Higgins, Marie Griffin, Tina V. Hartert

Research output: Contribution to journalArticlepeer-review

Abstract

We determined the prevalence of human metapneumovirus (hMPV) infection in adults with asthma who were prospectively enrolled after hospitalization for an acute asthma exacerbation. Nasal wash specimens collected at admission and 3 months after discharge were tested for hMPV by real-time reverse-transcription polymerase chain reaction assays. hMPV was detected in 7 (6.9%) of 101 subjects at hospitalization and in 1 (1.3%) of 75 subjects at follow-up (odds ratio, 7 [95% confidence interval, 0.9-312]; P = .03). None of the patients with hMPV infection at hospitalization tested positive at follow-up, strongly suggesting that hMPV plays a direct etiologic role in acute asthma exacerbations.

Original languageEnglish (US)
Pages (from-to)1149-1153
Number of pages5
JournalJournal of Infectious Diseases
Volume192
Issue number7
DOIs
StatePublished - Sep 1 2005

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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