Human keratinocyte Toll-like receptors promote distinct immune responses

Lloyd S. Miller; Robert L. Modlin

doi:10.1038/sj.jid.5700559

Human keratinocyte Toll-like receptors promote distinct immune responses

Lloyd S. Miller, Robert L. Modlin

Research output: Contribution to journal › Comment/debate › peer-review

65 Scopus citations

Abstract

It has been well established that Toll-like receptors (TLRs) are expressed by keratinocytes and respond to their respective ligands to initiate immune responses. However, it appears that keratinocytes, via differential activation of TLRs, may play a key role in determining the type of subsequent cutaneous immune response generated against a particular pathogen.

Original language	English (US)
Pages (from-to)	262-263
Number of pages	2
Journal	Journal of Investigative Dermatology
Volume	127
Issue number	2
DOIs	https://doi.org/10.1038/sj.jid.5700559
State	Published - Feb 2007
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Dermatology
Cell Biology

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abstract = "It has been well established that Toll-like receptors (TLRs) are expressed by keratinocytes and respond to their respective ligands to initiate immune responses. However, it appears that keratinocytes, via differential activation of TLRs, may play a key role in determining the type of subsequent cutaneous immune response generated against a particular pathogen.",

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AB - It has been well established that Toll-like receptors (TLRs) are expressed by keratinocytes and respond to their respective ligands to initiate immune responses. However, it appears that keratinocytes, via differential activation of TLRs, may play a key role in determining the type of subsequent cutaneous immune response generated against a particular pathogen.

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Human keratinocyte Toll-like receptors promote distinct immune responses

Abstract

ASJC Scopus subject areas

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