Human in vivo phosphate metabolite imaging with 31P NMR

Paul A Bottomley, H. C. Charles, P. B. Roemer, D. Flamig, H. Engeseth, W. A. Edelstein, O. M. Mueller

Research output: Contribution to journalArticle

Abstract

Phosphorus (31P) spectroscopic images showing the distribution of high-energy phosphate metabolites in the human brain have been obtained at 1.5 T in scan times of 8.5 to 34 min at 27 and 64 cm3 spatial resolution using pulsed phase-encoding gradient magnetic fields and three-dimensional Fourier transform (3DFT) techniques. Data were acquired as free induction decays with a quadrature volume NMR detection coil of a truncated geometry designed to optimize the signal-to-noise ratio on the coil axis on the assumption that the sample noise represents the dominant noise source, and shelf-shielded magnetic field gradient coils to minimize eddy-current effects. The images permit comparison of metabolic data acquired simultaneously from different locations in the brain, as well as metabolite quantification by inclusion of a vial containing a standard of known 31P concentration in the image array. Values for the NMR visible adenosine triphosphate in three individuals were about 3 mM of tissue. The ratio of NMR detectable phosphocreatine to ATP in brain was 1.15 ± 0.17 SD in these experiments. Potential sources of random and systematic error in these and other 31P measurements are identified.

Original languageEnglish (US)
Pages (from-to)319-336
Number of pages18
JournalMagnetic Resonance in Medicine
Volume7
Issue number3
StatePublished - 1988
Externally publishedYes

Fingerprint

Phosphates
Magnetic Fields
Noise
Brain
Adenosine Triphosphate
Phosphocreatine
Signal-To-Noise Ratio
Fourier Analysis
Phosphorus

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Bottomley, P. A., Charles, H. C., Roemer, P. B., Flamig, D., Engeseth, H., Edelstein, W. A., & Mueller, O. M. (1988). Human in vivo phosphate metabolite imaging with 31P NMR. Magnetic Resonance in Medicine, 7(3), 319-336.

Human in vivo phosphate metabolite imaging with 31P NMR. / Bottomley, Paul A; Charles, H. C.; Roemer, P. B.; Flamig, D.; Engeseth, H.; Edelstein, W. A.; Mueller, O. M.

In: Magnetic Resonance in Medicine, Vol. 7, No. 3, 1988, p. 319-336.

Research output: Contribution to journalArticle

Bottomley, PA, Charles, HC, Roemer, PB, Flamig, D, Engeseth, H, Edelstein, WA & Mueller, OM 1988, 'Human in vivo phosphate metabolite imaging with 31P NMR', Magnetic Resonance in Medicine, vol. 7, no. 3, pp. 319-336.
Bottomley PA, Charles HC, Roemer PB, Flamig D, Engeseth H, Edelstein WA et al. Human in vivo phosphate metabolite imaging with 31P NMR. Magnetic Resonance in Medicine. 1988;7(3):319-336.
Bottomley, Paul A ; Charles, H. C. ; Roemer, P. B. ; Flamig, D. ; Engeseth, H. ; Edelstein, W. A. ; Mueller, O. M. / Human in vivo phosphate metabolite imaging with 31P NMR. In: Magnetic Resonance in Medicine. 1988 ; Vol. 7, No. 3. pp. 319-336.
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