Human immunodeficiency virus type 1-specific immunity after genetic immunization is enhanced by modification of Gag and Pol expression

Y. Huang, W. P. Kong, G. J. Nabel

Research output: Contribution to journalArticle

Abstract

Immunity to human immunodeficiency virus virion-like structures or a polyprotein has been examined after DNA immunization with Rev-independent expression vectors. A Gag-Pol fusion protein stimulated cytotoxic T lymphocyte and antibody responses to Gag and Pol, while a Gag-Pol pseudoparticle did not elicit substantial Pol responses. This fusion protein may be useful for AIDS vaccines.

Original languageEnglish (US)
Pages (from-to)4947-4951
Number of pages5
JournalJournal of Virology
Volume75
Issue number10
DOIs
StatePublished - 2001
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology

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