Human immunodeficiency virus type 1 coat protein neurotoxicity mediated by nitric oxide in primary cortical cultures

Valina L. Dawson; Ted M. Dawson; George R. Uhl; Solomon H. Snyder

Human immunodeficiency virus type 1 coat protein neurotoxicity mediated by nitric oxide in primary cortical cultures

Valina L. Dawson, Ted M. Dawson, George R. Uhl, Solomon H. Snyder

School of Medicine

Research output: Contribution to journal › Article › peer-review

323 Scopus citations

Abstract

The human immunodeficiency virus type 1 coat protein, gp120, kills neurons in primary cortical cultures at low picomolar concentrations. The toxicity requires external glutamate and calcium and is blocked by glutamate receptor antagonists. Nitric oxide (NO) contributes to gp120 toxicity, since nitroarginine, an inhibitor of NO synthase, prevents toxicity as does deletion of arginine from the incubation medium and hemoglobin, which binds NO. Superoxide dismutase also attenuates toxicity, implying a role for superoxide anions.

Original language	English (US)
Pages (from-to)	3256-3259
Number of pages	4
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	90
Issue number	8
State	Published - Apr 15 1993

Keywords

AIDS
Glutamate
Gp120
Microglia
N-methyl-D-aspartate

ASJC Scopus subject areas

General

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Human immunodeficiency virus type 1 coat protein neurotoxicity mediated by nitric oxide in primary cortical cultures. / Dawson, Valina L.; Dawson, Ted M.; Uhl, George R. et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, No. 8, 15.04.1993, p. 3256-3259.

Research output: Contribution to journal › Article › peer-review

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Human immunodeficiency virus type 1 coat protein neurotoxicity mediated by nitric oxide in primary cortical cultures

Abstract

Keywords

ASJC Scopus subject areas

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