Human immunodeficiency virus type 1 coat protein neurotoxicity mediated by nitric oxide in primary cortical cultures

Research output: Contribution to journalArticle

Abstract

The human immunodeficiency virus type 1 coat protein, gp120, kills neurons in primary cortical cultures at low picomolar concentrations. The toxicity requires external glutamate and calcium and is blocked by glutamate receptor antagonists. Nitric oxide (NO) contributes to gp120 toxicity, since nitroarginine, an inhibitor of NO synthase, prevents toxicity as does deletion of arginine from the incubation medium and hemoglobin, which binds NO. Superoxide dismutase also attenuates toxicity, implying a role for superoxide anions.

Original languageEnglish (US)
Pages (from-to)3256-3259
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume90
Issue number8
StatePublished - Apr 15 1993

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Capsid Proteins
HIV-1
Nitric Oxide
Excitatory Amino Acid Antagonists
Nitroarginine
Nitric Oxide Synthase
Superoxides
Superoxide Dismutase
Arginine
Glutamic Acid
Hemoglobins
Calcium
Neurons

Keywords

  • AIDS
  • Glutamate
  • Gp120
  • Microglia
  • N-methyl-D-aspartate

ASJC Scopus subject areas

  • General
  • Genetics

Cite this

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