Human immunodeficiency virus infection of human bone marrow stromal fibroblasts

D. T. Scadden, M. Zeira, A. Woon, Z. Wang, L. Schieve, K. Ikeuchi, B. Lim, J. E. Groopman

Research output: Contribution to journalArticle

Abstract

The human immunodeficiency virus (HIV) preferentially infects CD4 positive T cells and monocytes. Other human cell types have been reported to be infectable with HIV, including cells of mesenchymal origin. In this report, we show that both primary human bone marrow stromal fibroblasts and an immortalized human stromal fibroblast line are susceptible to HIV infection. These cells are capable of passing HIV to cells of lymphoid or myeloid lineage, and may thereby act as a reservoir of virus. This in vitro system may be a useful model for assessing the pathophysiology of hematopoietic dysfunction in AIDS patients.

Original languageEnglish (US)
Pages (from-to)317-322
Number of pages6
JournalBlood
Volume76
Issue number2
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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  • Cite this

    Scadden, D. T., Zeira, M., Woon, A., Wang, Z., Schieve, L., Ikeuchi, K., Lim, B., & Groopman, J. E. (1990). Human immunodeficiency virus infection of human bone marrow stromal fibroblasts. Blood, 76(2), 317-322. https://doi.org/10.1182/blood.v76.2.317.317