TY - JOUR
T1 - Human Immunodeficiency Virus (HIV) type 1 antibodies in perinatal HIV-1 infection
T2 - Association with human HIV-1 transmission, infection, and disease progression
AU - for the Women and Infants Transmission Study (WITS)
AU - Pitt, Jane
AU - Henrard, Denis
AU - FitzGerald, Gordon
AU - Mofenson, Lynne
AU - Lew, Judy
AU - Hillyer, George
AU - Mendez, Hermann
AU - Cooper, Ellen
AU - Hanson, Celine
AU - Rich, Kenneth C.
AU - Diaz, Clemente
AU - Pacheco-Acosta, Edna
AU - Tuomala, Ruth
AU - Cooper, Ellen
AU - Mesthene, Donna
AU - Pitt and, Jane
AU - Higgins, Alice
AU - Landesman, Sheldon
AU - Mendez, Hermann
AU - Moroso, Gail
AU - Rich, Kenneth
AU - Turpkin, Delmyra
AU - Shearer, William
AU - Hanson, Celine
AU - Cooper, Norma
AU - Fowler, Mary Glenn
AU - Lewn, Judy
AU - Matzen, Elaine
AU - Willoughby, Anne
AU - Burns, David
AU - Moye, Jack
AU - Read, Jennifer
AU - Mofenson, Lynne
AU - Smeriglio, Vincent
AU - McKinley, Sonja
AU - Kalish, Les
AU - Ellis, Susan
N1 - Funding Information:
Financial support: National Institute of Allergy and Infectious Disease/ National Institute of Child Health and Human Development/National Institute on Drug Abuse/National Institutes of Health (U01 AI 34858, U01 AI 34856, U01 AI 34842, U01 AI 34841, U01 AI 34840, N01 AI 35161, HD 8-2913, and R01 HD-25714).
PY - 2000
Y1 - 2000
N2 - Anti -human immunodeficiency virus (HIV) type 1 antibodies in 242 pregnant women and 238 infants were measured at birth and at 1, 2, 4, and 6 months after birth, to estimate their association with perinatal transmission and infant disease progression. Maternal anti-p24 (P = .01) and anti-gp120 (P = .04) antibodies were inversely associated with vertical transmission rates, independent of maternal percentage of CD4 cells, hard drug use, duration of ruptured membranes, serum albumin levels, serum vitamin A levels, and quantitative HIV-1 peripheral mononuclear blood cell culture, but not with maternal plasma immune complex dissociated p24 or HIV-1 RNA copy number, both of which were highly correlated with antibodies. From ages 1-2 months, anti-gp120, -gp41, -p31, and -p66 decayed to a greater extent in infected than in uninfected infants. Infected infants produced anti-p24 antibody by age 2 months, anti-p17 by 4 months, and anti-p41 and anti-gp120 by 6 months. As early as birth, infants with rapid disease progression had lower levels of anti-p24 than did infants whose disease did not rapidly progress, but not independently of HIV-1 RNA levels.
AB - Anti -human immunodeficiency virus (HIV) type 1 antibodies in 242 pregnant women and 238 infants were measured at birth and at 1, 2, 4, and 6 months after birth, to estimate their association with perinatal transmission and infant disease progression. Maternal anti-p24 (P = .01) and anti-gp120 (P = .04) antibodies were inversely associated with vertical transmission rates, independent of maternal percentage of CD4 cells, hard drug use, duration of ruptured membranes, serum albumin levels, serum vitamin A levels, and quantitative HIV-1 peripheral mononuclear blood cell culture, but not with maternal plasma immune complex dissociated p24 or HIV-1 RNA copy number, both of which were highly correlated with antibodies. From ages 1-2 months, anti-gp120, -gp41, -p31, and -p66 decayed to a greater extent in infected than in uninfected infants. Infected infants produced anti-p24 antibody by age 2 months, anti-p17 by 4 months, and anti-p41 and anti-gp120 by 6 months. As early as birth, infants with rapid disease progression had lower levels of anti-p24 than did infants whose disease did not rapidly progress, but not independently of HIV-1 RNA levels.
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U2 - 10.1086/315809
DO - 10.1086/315809
M3 - Article
C2 - 10979926
AN - SCOPUS:0033805297
SN - 0022-1899
VL - 182
SP - 1243
EP - 1246
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 4
ER -