Human immunodeficiency virus and the brain

Jonathan D. Glass, Richard T. Johnson

Research output: Contribution to journalReview articlepeer-review


Human immunodeficiency virus (HIV) infects the nervous system in the majority of patients, causing a variety of neurological syndromes throughout the course of the disease. This review focuses on the effects of HIV in the central nervous system, with an emphasis on HIV-associated dementia. HIV- associated dementia occurs in a subset of patients with AIDS; it is unclear why these patients and not all patients develop the disease. Several factors are likely to be involved in the pathogenesis of HIV-associated dementia, including neurotoxins released from the virus and/or infected macrophages and microglia, immunologic dysregulation of macrophage function, and specific genetic strains of HIV. These factors, and their possible interactions, are discussed.

Original languageEnglish (US)
Pages (from-to)1-26
Number of pages26
JournalAnnual review of neuroscience
StatePublished - 1996


  • AIDS
  • dementia
  • neurology
  • neuropathology
  • neurotoxicity

ASJC Scopus subject areas

  • Neuroscience(all)


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