Human immunodeficiency virus-1 RNA levels and CD4 lymphocyte counts, during treatment for active tuberculosis, in South African patients

Lynn Morris, Desmond J. Martin, Helba Bredell, Stephina N. Nyoka, Leonard Sacks, Stella Pendle, Liesl Page-Shipp, Christopher L. Karp, Timothy R. Sterling, Thomas C. Quinn, Richard E. Chaisson

Research output: Contribution to journalArticle

Abstract

During 6 months of treatment, we measured human immunodeficiency virus (HIV)-1 virus loads, CD4 T cell counts, and immune activation markers, in 111 HIV-1-infected patients with active tuberculosis (TB). The median virus load (baseline, 5.58 log10 copies/mL) significantly increased at 1 month (5.71 log10 copies/mL), then returned to near-baseline levels at 3 months (5.40 log10 copies/mL) and at 6 months (5.36 log10 copies/mL). In contrast, the median CD4 counts increased at 1 month (186/mm3), at 3 months (238/mm3), and at 6 months (239/mm3). CD4 counts and virus loads did not change during therapy. Expression of CD38 and HLA-DR remained high throughout treatment, whereas plasma levels of interleukin-6 decreased over time.

Original languageEnglish (US)
Pages (from-to)1967-1971
Number of pages5
JournalJournal of Infectious Diseases
Volume187
Issue number12
DOIs
StatePublished - Jun 15 2003
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    Morris, L., Martin, D. J., Bredell, H., Nyoka, S. N., Sacks, L., Pendle, S., Page-Shipp, L., Karp, C. L., Sterling, T. R., Quinn, T. C., & Chaisson, R. E. (2003). Human immunodeficiency virus-1 RNA levels and CD4 lymphocyte counts, during treatment for active tuberculosis, in South African patients. Journal of Infectious Diseases, 187(12), 1967-1971. https://doi.org/10.1086/375346