Human immunodeficiency virus-1 RNA levels and CD4 lymphocyte counts, during treatment for active tuberculosis, in South African patients

Lynn Morris; Desmond J. Martin; Helba Bredell; Stephina N. Nyoka; Leonard Sacks; Stella Pendle; Liesl Page-Shipp; Christopher L. Karp; Timothy R. Sterling; Thomas C. Quinn; Richard E. Chaisson

doi:10.1086/375346

Human immunodeficiency virus-1 RNA levels and CD4 lymphocyte counts, during treatment for active tuberculosis, in South African patients

Lynn Morris, Desmond J. Martin, Helba Bredell, Stephina N. Nyoka, Leonard Sacks, Stella Pendle, Liesl Page-Shipp, Christopher L. Karp, Timothy R. Sterling, Thomas C. Quinn, Richard E. Chaisson

School of Medicine

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

During 6 months of treatment, we measured human immunodeficiency virus (HIV)-1 virus loads, CD4 T cell counts, and immune activation markers, in 111 HIV-1-infected patients with active tuberculosis (TB). The median virus load (baseline, 5.58 log₁₀ copies/mL) significantly increased at 1 month (5.71 log₁₀ copies/mL), then returned to near-baseline levels at 3 months (5.40 log₁₀ copies/mL) and at 6 months (5.36 log₁₀ copies/mL). In contrast, the median CD4 counts increased at 1 month (186/mm³), at 3 months (238/mm³), and at 6 months (239/mm³). CD4 counts and virus loads did not change during therapy. Expression of CD38 and HLA-DR remained high throughout treatment, whereas plasma levels of interleukin-6 decreased over time.

Original language	English (US)
Pages (from-to)	1967-1971
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	187
Issue number	12
DOIs	https://doi.org/10.1086/375346
State	Published - Jun 15 2003

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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Morris, L., Martin, D. J., Bredell, H., Nyoka, S. N., Sacks, L., Pendle, S., Page-Shipp, L., Karp, C. L., Sterling, T. R., Quinn, T. C., & Chaisson, R. E. (2003). Human immunodeficiency virus-1 RNA levels and CD4 lymphocyte counts, during treatment for active tuberculosis, in South African patients. Journal of Infectious Diseases, 187(12), 1967-1971. https://doi.org/10.1086/375346

Morris, L, Martin, DJ, Bredell, H, Nyoka, SN, Sacks, L, Pendle, S, Page-Shipp, L, Karp, CL, Sterling, TR, Quinn, TC & Chaisson, RE 2003, 'Human immunodeficiency virus-1 RNA levels and CD4 lymphocyte counts, during treatment for active tuberculosis, in South African patients', Journal of Infectious Diseases, vol. 187, no. 12, pp. 1967-1971. https://doi.org/10.1086/375346

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title = "Human immunodeficiency virus-1 RNA levels and CD4 lymphocyte counts, during treatment for active tuberculosis, in South African patients",

abstract = "During 6 months of treatment, we measured human immunodeficiency virus (HIV)-1 virus loads, CD4 T cell counts, and immune activation markers, in 111 HIV-1-infected patients with active tuberculosis (TB). The median virus load (baseline, 5.58 log10 copies/mL) significantly increased at 1 month (5.71 log10 copies/mL), then returned to near-baseline levels at 3 months (5.40 log10 copies/mL) and at 6 months (5.36 log10 copies/mL). In contrast, the median CD4 counts increased at 1 month (186/mm3), at 3 months (238/mm3), and at 6 months (239/mm3). CD4 counts and virus loads did not change during therapy. Expression of CD38 and HLA-DR remained high throughout treatment, whereas plasma levels of interleukin-6 decreased over time.",

author = "Lynn Morris and Martin, {Desmond J.} and Helba Bredell and Nyoka, {Stephina N.} and Leonard Sacks and Stella Pendle and Liesl Page-Shipp and Karp, {Christopher L.} and Sterling, {Timothy R.} and Quinn, {Thomas C.} and Chaisson, {Richard E.}",

note = "Funding Information: Financial support: Poliomyelitis Research Foundation of South Africa; National Institutes of Health Fogarty International Training Grant (2 D 43 TW000010); National Institute of Allergy and Infectious Diseases (grant K24-01637 to REC).",

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AU - Karp, Christopher L.

AU - Sterling, Timothy R.

AU - Quinn, Thomas C.

AU - Chaisson, Richard E.

N1 - Funding Information: Financial support: Poliomyelitis Research Foundation of South Africa; National Institutes of Health Fogarty International Training Grant (2 D 43 TW000010); National Institute of Allergy and Infectious Diseases (grant K24-01637 to REC).

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N2 - During 6 months of treatment, we measured human immunodeficiency virus (HIV)-1 virus loads, CD4 T cell counts, and immune activation markers, in 111 HIV-1-infected patients with active tuberculosis (TB). The median virus load (baseline, 5.58 log10 copies/mL) significantly increased at 1 month (5.71 log10 copies/mL), then returned to near-baseline levels at 3 months (5.40 log10 copies/mL) and at 6 months (5.36 log10 copies/mL). In contrast, the median CD4 counts increased at 1 month (186/mm3), at 3 months (238/mm3), and at 6 months (239/mm3). CD4 counts and virus loads did not change during therapy. Expression of CD38 and HLA-DR remained high throughout treatment, whereas plasma levels of interleukin-6 decreased over time.

AB - During 6 months of treatment, we measured human immunodeficiency virus (HIV)-1 virus loads, CD4 T cell counts, and immune activation markers, in 111 HIV-1-infected patients with active tuberculosis (TB). The median virus load (baseline, 5.58 log10 copies/mL) significantly increased at 1 month (5.71 log10 copies/mL), then returned to near-baseline levels at 3 months (5.40 log10 copies/mL) and at 6 months (5.36 log10 copies/mL). In contrast, the median CD4 counts increased at 1 month (186/mm3), at 3 months (238/mm3), and at 6 months (239/mm3). CD4 counts and virus loads did not change during therapy. Expression of CD38 and HLA-DR remained high throughout treatment, whereas plasma levels of interleukin-6 decreased over time.

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Human immunodeficiency virus-1 RNA levels and CD4 lymphocyte counts, during treatment for active tuberculosis, in South African patients

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