Human Ige-Specific autoantibodies and autoantibodies to IgE receptors

Immunoglobulin and its receptors on various cell types mediate immediate-type immune responses that are an important part of adaptive immune response in mammals. The limited production of naturally occurring antibodies specific for immunoglobulins such as IgE and the IgE receptor has been reported. Such antibodies have also been molecularly cloned from the human repertoire. They are believed to play an immunoregulatory function in the maintenance of immune system homeostasis. This review examines the significance of naturally occurring autoantibodies that bind to human IgE or its receptors and engineered monoclonal antibodies against Omalizumab ( IgE) and Lumiliximab (FcRII) that are used in the treatment of allergic diseases. IgE and its receptors are the critical components of immediate-type hypersensitivity. Naturally occurring autoantibodies to human IgE or its receptors have been described and the clinical significance remains under study, but may be important in urticaria. Anti-IgE therapy has become standard of care for moderate to severe asthma.