TY - JOUR
T1 - Human herpesvirus 8 infection and Kaposi's sarcoma among human immunodeficiency virus-infected and -uninfected women
AU - Greenblatt, Ruth M.
AU - Jacobson, Lisa P.
AU - Levine, Alexandra M.
AU - Melnick, Sandra
AU - Anastos, Kathryn
AU - Cohen, Mardge
AU - DeHovitz, Jack
AU - Young, Mary A.
AU - Burns, David
AU - Miotti, Paolo
AU - Koelle, David M.
N1 - Funding Information:
Financial support: Cooperative agreement issued by the National Institute of Allergy and Infectious Diseases, the National Institute of Child Health and Human Development, the National Institute for Dental Research, and the National Cancer Institute and National Center for Research Resources grants 5-MO1-RR-00079 and 5-MO1-RR-00083-379.
PY - 2001/4/1
Y1 - 2001/4/1
N2 - Little is known about the epidemiology of human herpesvirus 8 (HHV-8) infections among women. A cross-sectional study was conducted of HHV-8 infection among human immunodeficiency virus (HIV)-infected and high-risk HIV-uninfected women. Serological tests with noninduced (latent) and induced (lytic) HHV-8 antigens were used to detect infection among 2483 participants of a multisite cohort. Reactivity to latent antigen was present in 4.1% and to induced antigens in 12.0% of women. Seven of 8 women who reported Kaposi's sarcoma had HHV-8 antibodies. Among HIV-positive women, HHV-8 infection was associated with use of crack, cocaine, or heroin (76% vs. 65%; P < .001), past syphilis (29% vs. 20%; P < .001), an injection drug-using male sex partner (61% vs. 53%; P = .014), black race (P = .010), and enrollment site (P = .015). In multivariate analysis, HIV infection, older age, past syphilis, black race, and enrollment site were independently associated with HHV-8 infection. In this cohort of North American women, HHV-8 infection was associated with HIV infection, drug use, and risky sexual behavior.
AB - Little is known about the epidemiology of human herpesvirus 8 (HHV-8) infections among women. A cross-sectional study was conducted of HHV-8 infection among human immunodeficiency virus (HIV)-infected and high-risk HIV-uninfected women. Serological tests with noninduced (latent) and induced (lytic) HHV-8 antigens were used to detect infection among 2483 participants of a multisite cohort. Reactivity to latent antigen was present in 4.1% and to induced antigens in 12.0% of women. Seven of 8 women who reported Kaposi's sarcoma had HHV-8 antibodies. Among HIV-positive women, HHV-8 infection was associated with use of crack, cocaine, or heroin (76% vs. 65%; P < .001), past syphilis (29% vs. 20%; P < .001), an injection drug-using male sex partner (61% vs. 53%; P = .014), black race (P = .010), and enrollment site (P = .015). In multivariate analysis, HIV infection, older age, past syphilis, black race, and enrollment site were independently associated with HHV-8 infection. In this cohort of North American women, HHV-8 infection was associated with HIV infection, drug use, and risky sexual behavior.
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U2 - 10.1086/319270
DO - 10.1086/319270
M3 - Article
C2 - 11237842
AN - SCOPUS:0035313394
SN - 0022-1899
VL - 183
SP - 1130
EP - 1134
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 7
ER -