Human herpesvirus-8

Maura L. Gillison, Richard F. Ambinder

Research output: Contribution to journalReview article

Abstract

Our current understanding of Kaposi's sarcoma (KS) has evolved from initial descriptions of this 'idiopathic sarcoma' to a progressively detailed characterization of its probable infectious origin. This article traces the explosive discovery of human herpesvirus-8 (HHV-8) and its etiologic associations with KS, Castleman's disease, and primary effusion lymphomas. A framework for understanding how viral infection leads to development of these unusual diseases is presented. The possible role of HHV-8 in tumorigenesis, through viral manipulation of signal transduction pathways and cell cycle control, is discussed.

Original languageEnglish (US)
Pages (from-to)440-449
Number of pages10
JournalCurrent opinion in oncology
Volume9
Issue number5
DOIs
StatePublished - Jan 1 1997

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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