Abstract
Our current understanding of Kaposi's sarcoma (KS) has evolved from initial descriptions of this 'idiopathic sarcoma' to a progressively detailed characterization of its probable infectious origin. This article traces the explosive discovery of human herpesvirus-8 (HHV-8) and its etiologic associations with KS, Castleman's disease, and primary effusion lymphomas. A framework for understanding how viral infection leads to development of these unusual diseases is presented. The possible role of HHV-8 in tumorigenesis, through viral manipulation of signal transduction pathways and cell cycle control, is discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 440-449 |
| Number of pages | 10 |
| Journal | Current opinion in oncology |
| Volume | 9 |
| Issue number | 5 |
| DOIs | |
| State | Published - Jan 1 1997 |
ASJC Scopus subject areas
- Oncology
- Cancer Research
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Cite this
Gillison, M. L., & Ambinder, R. F. (1997). Human herpesvirus-8. Current opinion in oncology, 9(5), 440-449. https://doi.org/10.1097/00001622-199709050-00008