TY - JOUR
T1 - Human herpesvirus-8
AU - Gillison, Maura L.
AU - Ambinder, Richard F.
PY - 1997/1/1
Y1 - 1997/1/1
N2 - Our current understanding of Kaposi's sarcoma (KS) has evolved from initial descriptions of this 'idiopathic sarcoma' to a progressively detailed characterization of its probable infectious origin. This article traces the explosive discovery of human herpesvirus-8 (HHV-8) and its etiologic associations with KS, Castleman's disease, and primary effusion lymphomas. A framework for understanding how viral infection leads to development of these unusual diseases is presented. The possible role of HHV-8 in tumorigenesis, through viral manipulation of signal transduction pathways and cell cycle control, is discussed.
AB - Our current understanding of Kaposi's sarcoma (KS) has evolved from initial descriptions of this 'idiopathic sarcoma' to a progressively detailed characterization of its probable infectious origin. This article traces the explosive discovery of human herpesvirus-8 (HHV-8) and its etiologic associations with KS, Castleman's disease, and primary effusion lymphomas. A framework for understanding how viral infection leads to development of these unusual diseases is presented. The possible role of HHV-8 in tumorigenesis, through viral manipulation of signal transduction pathways and cell cycle control, is discussed.
UR - http://www.scopus.com/inward/record.url?scp=0030817697&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030817697&partnerID=8YFLogxK
U2 - 10.1097/00001622-199709050-00008
DO - 10.1097/00001622-199709050-00008
M3 - Review article
C2 - 9327222
AN - SCOPUS:0030817697
SN - 1040-8746
VL - 9
SP - 440
EP - 449
JO - Current opinion in oncology
JF - Current opinion in oncology
IS - 5
ER -