Human herpesvirus 6 (strain U1102) encodes homologues of the conserved herpesvirus glycoprotein gM and the alphaherpesvirus origin-binding protein

G. L. Lawrence, John Nicholas, B. G. Barrell

Research output: Contribution to journalArticle

Abstract

The nucleotide sequence of 3134 bp from the genome of human herpesvirus 6 (HHV-6) strain U1102 was determined. The sequence overlaps and is contiguous with the 21 858 bp nucleotide sequence published by us previously. The sequence reported here encodes two open reading frames, named 18L and 19R. The protein encoded by 18L shares amino acid sequence similarity with the multiply hydrophobic glycoprotein M conserved in the genomes of all herpesviruses sequenced to date. ORF 19R encodes a protein which shares a significant degree of amino acid sequence conservation with the origin-binding protein homologues encoded by members of the alphaherpesviurs subgroup, but does not share detectable amino acid sequence homology with positionaly analogous open reading frames present in the genomes of other betaherpesviruses or in the genomes of gammaherpesviruses.

Original languageEnglish (US)
Pages (from-to)147-152
Number of pages6
JournalJournal of General Virology
Volume76
Issue number1
StatePublished - 1995
Externally publishedYes

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Human Herpesvirus 6
Herpesviridae
Glycoproteins
Carrier Proteins
Genome
Open Reading Frames
Amino Acid Sequence
Amino Acid Sequence Homology
Proteins

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

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abstract = "The nucleotide sequence of 3134 bp from the genome of human herpesvirus 6 (HHV-6) strain U1102 was determined. The sequence overlaps and is contiguous with the 21 858 bp nucleotide sequence published by us previously. The sequence reported here encodes two open reading frames, named 18L and 19R. The protein encoded by 18L shares amino acid sequence similarity with the multiply hydrophobic glycoprotein M conserved in the genomes of all herpesviruses sequenced to date. ORF 19R encodes a protein which shares a significant degree of amino acid sequence conservation with the origin-binding protein homologues encoded by members of the alphaherpesviurs subgroup, but does not share detectable amino acid sequence homology with positionaly analogous open reading frames present in the genomes of other betaherpesviruses or in the genomes of gammaherpesviruses.",
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AB - The nucleotide sequence of 3134 bp from the genome of human herpesvirus 6 (HHV-6) strain U1102 was determined. The sequence overlaps and is contiguous with the 21 858 bp nucleotide sequence published by us previously. The sequence reported here encodes two open reading frames, named 18L and 19R. The protein encoded by 18L shares amino acid sequence similarity with the multiply hydrophobic glycoprotein M conserved in the genomes of all herpesviruses sequenced to date. ORF 19R encodes a protein which shares a significant degree of amino acid sequence conservation with the origin-binding protein homologues encoded by members of the alphaherpesviurs subgroup, but does not share detectable amino acid sequence homology with positionaly analogous open reading frames present in the genomes of other betaherpesviruses or in the genomes of gammaherpesviruses.

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