Human growth hormone treatment of children with growth failure and normal growth hormone levels by immunoassay: Lack of correlation with somatomedin generation

L. P. Plotnick, Q. L. Van Meter, A. A. Kowarski

Research output: Contribution to journalArticle

Abstract

Children with growth failure, normal growth hormone responses to stimulation tests, and low somatomedin levels are being recognized with increasing frequency. Sixteen patients, aged 2 to 17 years, with these findings were studied. When treated with human growth hormone, the mean plasma somatomedin-C levels of these patients increased from 0.19 ± 0.05 (SD) U/mL to 2.29 ± 1.11 U/mL (P < .001) and mean growth velocity increased from 3.6 ± 1.6 (SD) cm/yr to 7.4 ± 2.9 cm/yr at 8 months of treatment (P < .001). The effect of human growth hormone therapy on the whole group was statistically significant, but the effect on individuals was highly variable. There was no correlation between magnitude of the increase in somatomedin-C and growth response (r = .26 NS). Thus, the long-term growth-promoting effect of human growth hormone therapy in this group of patients could not be predicted from the magnitude of the somatomedin-C responses.

Original languageEnglish (US)
Pages (from-to)324-327
Number of pages4
JournalPediatrics
Volume71
Issue number3
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'Human growth hormone treatment of children with growth failure and normal growth hormone levels by immunoassay: Lack of correlation with somatomedin generation'. Together they form a unique fingerprint.

  • Cite this