Human granulocyte collagenase

Gerald S. Lazarus; Robert S. Brown; John R. Daniels; Harold M. Fullmer

doi:10.1126/science.159.3822.1483

Human granulocyte collagenase

Gerald S. Lazarus, Robert S. Brown, John R. Daniels, Harold M. Fullmer

Research output: Contribution to journal › Article › peer-review

221 Scopus citations

Abstract

A collagenase, operative at neutral and alkaline pH, has been extracted from the granule fraction of human granulocytic leukocytes. It digests reconstituted collagen fibrils and reduces the viscosity of collagen solutions. Cleavage of collagen in solution with purified enzyme produces the discrete products characteristic of other animal collagenases.

Original language	English (US)
Pages (from-to)	1483-1485
Number of pages	3
Journal	Science
Volume	159
Issue number	3822
DOIs	https://doi.org/10.1126/science.159.3822.1483
State	Published - 1968
Externally published	Yes

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@article{5ebe012febce46e1ba5859b917de773c,

title = "Human granulocyte collagenase",

abstract = "A collagenase, operative at neutral and alkaline pH, has been extracted from the granule fraction of human granulocytic leukocytes. It digests reconstituted collagen fibrils and reduces the viscosity of collagen solutions. Cleavage of collagen in solution with purified enzyme produces the discrete products characteristic of other animal collagenases.",

author = "Lazarus, {Gerald S.} and Brown, {Robert S.} and Daniels, {John R.} and Fullmer, {Harold M.}",

year = "1968",

doi = "10.1126/science.159.3822.1483",

language = "English (US)",

volume = "159",

pages = "1483--1485",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "3822",

}

TY - JOUR

T1 - Human granulocyte collagenase

AU - Lazarus, Gerald S.

AU - Brown, Robert S.

AU - Daniels, John R.

AU - Fullmer, Harold M.

PY - 1968

Y1 - 1968

N2 - A collagenase, operative at neutral and alkaline pH, has been extracted from the granule fraction of human granulocytic leukocytes. It digests reconstituted collagen fibrils and reduces the viscosity of collagen solutions. Cleavage of collagen in solution with purified enzyme produces the discrete products characteristic of other animal collagenases.

AB - A collagenase, operative at neutral and alkaline pH, has been extracted from the granule fraction of human granulocytic leukocytes. It digests reconstituted collagen fibrils and reduces the viscosity of collagen solutions. Cleavage of collagen in solution with purified enzyme produces the discrete products characteristic of other animal collagenases.

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UR - http://www.scopus.com/inward/citedby.url?scp=0014423749&partnerID=8YFLogxK

U2 - 10.1126/science.159.3822.1483

DO - 10.1126/science.159.3822.1483

M3 - Article

C2 - 4297235

AN - SCOPUS:0014423749

SN - 0036-8075

VL - 159

SP - 1483

EP - 1485

JO - Science

JF - Science

IS - 3822

ER -

Human granulocyte collagenase

Abstract

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