Human genetic variants of homologous recombination repair genes first found to be associated with Epstein-Barr virus antibody titers in healthy Cantonese

Guo Ping Shen, Qing Hua Pan, Ming Huang Hong, Hai De Qin, Ya Fei Xu, Li Zhen Chen, Qi Sheng Feng, Timothy J. Jorgensen, Yin Yao Shugart, Yi Xin Zeng, Wei Hua Jia

Research output: Contribution to journalArticlepeer-review

Abstract

Epstein-Barr virus (EBV) infection is a major risk factor for nasopharyngeal carcinoma (NPC). Despite high prevalence of infection among the general population worldwide, only a small proportion of infected individuals presents with seropositivity for EBV-specific IgA antibodies. This seropositive subgroup of EBV carriers has an elevated cumulative risk for NPC during their lifetime. Previous studies reported that the host homologous recombination repair (HRR) system participates in EBV lytic replication, suggesting a potential mechanism to influence EBV reactivation status and thus seropositivity. To investigate whether genetic variants of HRR genes are associated with the serostatus in a healthy population, we investigated the association between seropositivity for anti-VCA-IgA and 156 tagging SNPs in 35 genes connected with HRR in an observational study among 755 healthy Cantonese speakers in southern China. Six variant alleles of MDC1, RAD54L, TP53BP1, RPA1, LIG3 and RFC1 exhibited associations with seropositivity (ptrend from 0.0085 to 0.00027). Our study provides evidence that genetic variation within the HRR might affect an individual's propensity for EBV seropositive status of anti-VCA IgA antibody.

Original languageEnglish (US)
Pages (from-to)1459-1466
Number of pages8
JournalInternational Journal of Cancer
Volume129
Issue number6
DOIs
StatePublished - Sep 15 2011

Keywords

  • Epstein-Barr virus
  • antiviral capsid antigen
  • homologous recombination repair
  • nasopharyngeal carcinoma
  • single nucleotide polymorphism

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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