Human enteroids: Preclinical models of non-inflammatory diarrhea

Olga Kovbasnjuk, Nicholas C. Zachos, Julie In, Jennifer Foulke-Abel, Khalil Ettayebi, Joseph M. Hyser, James R. Broughman, Xi Lei Zeng, Sabine Middendorp, Hugo R. De Jonge, Mary K. Estes, Mark Donowitz

Research output: Contribution to journalReview article

Abstract

Researchers need an available and easy-to-use model of the human intestine to better understand human intestinal physiology and pathophysiology of diseases, and to offer an enhanced platform for developing drug therapy. Our work employs human enteroids derived from each of the major intestinal sections to advance understanding of several diarrheal diseases, including those caused by cholera, rotavirus and enterohemorrhagic Escherichia coli. An enteroid bank is being established to facilitate comparison of segmental, developmental, and regulatory differences in transport proteins that can influence therapy efficacy. Basic characterization of major ion transport protein expression, localization and function in the human enteroid model sets the stage to study the effects of enteric infection at the transport level, as well as to monitor potential responses to pharmacological intervention.

Original languageEnglish (US)
Article numberS3
JournalStem Cell Research and Therapy
Volume4
Issue numberSUPPL.1
DOIs
StatePublished - Dec 20 2013

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ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Molecular Medicine
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Cell Biology

Cite this

Kovbasnjuk, O., Zachos, N. C., In, J., Foulke-Abel, J., Ettayebi, K., Hyser, J. M., Broughman, J. R., Zeng, X. L., Middendorp, S., De Jonge, H. R., Estes, M. K., & Donowitz, M. (2013). Human enteroids: Preclinical models of non-inflammatory diarrhea. Stem Cell Research and Therapy, 4(SUPPL.1), [S3]. https://doi.org/10.1186/scrt364