Human disease in Europe caused by a granulocytic Ehrlichia species

Miroslav Petrovec, Stanka Lotric Furlan, Tatjana Avsic Zupanc, Franc Strle, Philippe Brouqui, Veronique Roux, J. Stephen Dumler

Research output: Contribution to journalArticle

Abstract

Human granulocytic ehrlichiosis (HGE) was recently described in North America. It is caused by an Ehrlichia species closely related to Ehrlichia phagocytophila and Ehrlichia equi, recognized to infect mostly ruminants and horses, respectively. The vector in North America is the tick Ixodes scapularis, which is also the vector of the Lyme disease agent, Borrelia burgdorferi. Previous serologic studies in patients with a diagnosis of Lyme borreliosis indicate that HGE may exist in Europe. We report the first documented case of HGE in Europe. The diagnosis was established by seroconversion to E. equi and the HGE agent and by PCR with sequence analysis of the gene encoding the HGE agent 16S rRNA. Interestingly, the patient presented with a self-limited but moderately severe illness. Thus, European physicians need to be aware that HGE exists in Europe and that the diagnosis should be considered in febrile patients with tick bites in areas where Lyme disease is endemic.

Original languageEnglish (US)
Pages (from-to)1556-1559
Number of pages4
JournalJournal of Clinical Microbiology
Volume35
Issue number6
StatePublished - Jun 1997

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Ehrlichia
Ehrlichiosis
Anaplasma phagocytophilum
Lyme Disease
North America
Tick Bites
Ixodes
Borrelia burgdorferi
Ruminants
Ticks
Horses
Sequence Analysis
Fever
Physicians
Polymerase Chain Reaction
Genes

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

Cite this

Petrovec, M., Furlan, S. L., Zupanc, T. A., Strle, F., Brouqui, P., Roux, V., & Dumler, J. S. (1997). Human disease in Europe caused by a granulocytic Ehrlichia species. Journal of Clinical Microbiology, 35(6), 1556-1559.

Human disease in Europe caused by a granulocytic Ehrlichia species. / Petrovec, Miroslav; Furlan, Stanka Lotric; Zupanc, Tatjana Avsic; Strle, Franc; Brouqui, Philippe; Roux, Veronique; Dumler, J. Stephen.

In: Journal of Clinical Microbiology, Vol. 35, No. 6, 06.1997, p. 1556-1559.

Research output: Contribution to journalArticle

Petrovec, M, Furlan, SL, Zupanc, TA, Strle, F, Brouqui, P, Roux, V & Dumler, JS 1997, 'Human disease in Europe caused by a granulocytic Ehrlichia species', Journal of Clinical Microbiology, vol. 35, no. 6, pp. 1556-1559.
Petrovec M, Furlan SL, Zupanc TA, Strle F, Brouqui P, Roux V et al. Human disease in Europe caused by a granulocytic Ehrlichia species. Journal of Clinical Microbiology. 1997 Jun;35(6):1556-1559.
Petrovec, Miroslav ; Furlan, Stanka Lotric ; Zupanc, Tatjana Avsic ; Strle, Franc ; Brouqui, Philippe ; Roux, Veronique ; Dumler, J. Stephen. / Human disease in Europe caused by a granulocytic Ehrlichia species. In: Journal of Clinical Microbiology. 1997 ; Vol. 35, No. 6. pp. 1556-1559.
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