Human cytomegalovirus (HCMV) smallest capsid protein identified as product of short open reading frame located between HCMV UL48 and UL49

Wade Gibson, Kendra S. Clopper, William J. Britt, Michael K. Baxter

Research output: Contribution to journalArticle

Abstract

The capsid of cytomegalovirus contains an abundant, low-molecular- weight protein whose coding sequence within the viral genome had nut been identified. We have used a combination of biochemical and immunological techniques to demonstrate that this protein, called the smallest capsid protein in human cytomegalovirus, is encoded by a previously unidentified 225-bp open reading frame (ORF) located between ORFs UL48 and UL49. This short ORF, called UL48/49, is the positional homolog of herpes simplex virus ORF UL35 (encoding capsid protein VP26) and shows partial amino acid sequence identity to positional homologs in human herpes viruses 6 and 7.

Original languageEnglish (US)
Pages (from-to)5680-5683
Number of pages4
JournalJournal of virology
Volume70
Issue number8
StatePublished - Aug 1 1996

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ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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