Human cytomegalovirus-encoded α-chemokines exhibit high sequence variability in congenitally infected newborns

Ravit Arav-Boger; Charles B. Foster; Jian Chao Zong; Robert F. Pass

doi:10.1086/500508

Human cytomegalovirus-encoded α-chemokines exhibit high sequence variability in congenitally infected newborns

Ravit Arav-Boger, Charles B. Foster, Jian Chao Zong, Robert F. Pass

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Most congenital human cytomegalovirus (HCMV) infections are asymptomatic, but some lead to severe disease. We hypothesized that differences in disease manifestations may be partially explained by differences in viral strains. We recently reported an association between unique long (UL) 144 gene polymorphisms and clinical disease. We now report on the sequence heterogeneity of 2 potential HCMV virulence genes that encode α-chemokines: UL146 and UL147. These 2 genes were highly divergent in cultured isolates obtained from 23 newborns with congenital HCMV infection and were difficult to categorize. Unlike our findings for the contiguous UL144 gene, no specific UL146 or UL147 genotype was associated with disease outcome.

Original language	English (US)
Pages (from-to)	788-791
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	193
Issue number	6
DOIs	https://doi.org/10.1086/500508
State	Published - Mar 15 2006
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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title = "Human cytomegalovirus-encoded α-chemokines exhibit high sequence variability in congenitally infected newborns",

abstract = "Most congenital human cytomegalovirus (HCMV) infections are asymptomatic, but some lead to severe disease. We hypothesized that differences in disease manifestations may be partially explained by differences in viral strains. We recently reported an association between unique long (UL) 144 gene polymorphisms and clinical disease. We now report on the sequence heterogeneity of 2 potential HCMV virulence genes that encode α-chemokines: UL146 and UL147. These 2 genes were highly divergent in cultured isolates obtained from 23 newborns with congenital HCMV infection and were difficult to categorize. Unlike our findings for the contiguous UL144 gene, no specific UL146 or UL147 genotype was associated with disease outcome.",

author = "Ravit Arav-Boger and Foster, {Charles B.} and Zong, {Jian Chao} and Pass, {Robert F.}",

note = "Funding Information: Received 23 August 2005; accepted 14 October 2005; electronically published 8 February 2006. Potential conflicts of interest: none reported. Financial support: United Cerebral Palsy Research and Education Foundation; Johns Hopkins Clinician Scientist Award (to R.A.-B.); National Institutes of Health (grants P01-AI43681 and M01 RR00032). Reprints or correspondence: Dr. Ravit Arav-Boger, Div. of Infectious Diseases, Dept. of Pediatrics, Johns Hopkins Hospital/Park 256, Baltimore, MD 21287 (boger@jhmi.edu).",

year = "2006",

month = mar,

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doi = "10.1086/500508",

language = "English (US)",

volume = "193",

pages = "788--791",

journal = "Journal of Infectious Diseases",

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T1 - Human cytomegalovirus-encoded α-chemokines exhibit high sequence variability in congenitally infected newborns

AU - Arav-Boger, Ravit

AU - Foster, Charles B.

AU - Zong, Jian Chao

AU - Pass, Robert F.

N1 - Funding Information: Received 23 August 2005; accepted 14 October 2005; electronically published 8 February 2006. Potential conflicts of interest: none reported. Financial support: United Cerebral Palsy Research and Education Foundation; Johns Hopkins Clinician Scientist Award (to R.A.-B.); National Institutes of Health (grants P01-AI43681 and M01 RR00032). Reprints or correspondence: Dr. Ravit Arav-Boger, Div. of Infectious Diseases, Dept. of Pediatrics, Johns Hopkins Hospital/Park 256, Baltimore, MD 21287 (boger@jhmi.edu).

PY - 2006/3/15

Y1 - 2006/3/15

N2 - Most congenital human cytomegalovirus (HCMV) infections are asymptomatic, but some lead to severe disease. We hypothesized that differences in disease manifestations may be partially explained by differences in viral strains. We recently reported an association between unique long (UL) 144 gene polymorphisms and clinical disease. We now report on the sequence heterogeneity of 2 potential HCMV virulence genes that encode α-chemokines: UL146 and UL147. These 2 genes were highly divergent in cultured isolates obtained from 23 newborns with congenital HCMV infection and were difficult to categorize. Unlike our findings for the contiguous UL144 gene, no specific UL146 or UL147 genotype was associated with disease outcome.

AB - Most congenital human cytomegalovirus (HCMV) infections are asymptomatic, but some lead to severe disease. We hypothesized that differences in disease manifestations may be partially explained by differences in viral strains. We recently reported an association between unique long (UL) 144 gene polymorphisms and clinical disease. We now report on the sequence heterogeneity of 2 potential HCMV virulence genes that encode α-chemokines: UL146 and UL147. These 2 genes were highly divergent in cultured isolates obtained from 23 newborns with congenital HCMV infection and were difficult to categorize. Unlike our findings for the contiguous UL144 gene, no specific UL146 or UL147 genotype was associated with disease outcome.

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Human cytomegalovirus-encoded α-chemokines exhibit high sequence variability in congenitally infected newborns

Abstract

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